Table 2.

Correlation coefficient of disease activity at W6, W10, or W14 with disease activity, HAQ score, and ΔTSS at W54.

Correlation	3 mg/kg, n = 99		6 mg/kg, n = 104		10 mg/kg, n = 104
	Coefficient	p	Coefficient	p	Coefficient	p
With SDAI at W54
SDAI at W6	0.563	< 0.0001	0.453	< 0.0001	0.260	0.0078
SDAI at W10	0.703	< 0.0001	0.513	< 0.0001	0.274	0.0049
SDAI at W14	0.665	< 0.0001	0.547	< 0.0001	0.500	< 0.0001
ΔSDAI at W14	−0.292	0.0034	−0.298	0.0022	−0.477	< 0.0001
Improvement, %, of SDAI at W14	−0.541	< 0.0001	−0.501	< 0.0001	−0.612	< 0.0001
With DAS28-CRP at W54
DAS28-CRP at W6	0.548	< 0.0001	0.537	< 0.0001	0.364	0.0001
DAS28-CRP at W10	0.662	< 0.0001	0.608	< 0.0001	0.440	< 0.0001
DAS28-CRP at W14	0.666	< 0.0001	0.666	< 0.0001	0.553	< 0.0001
ΔDAS28-CRP at W14	−0.497	< 0.0001	−0.522	< 0.0001	−0.564	< 0.0001
Improvement, %, of DAS28-CRP at W14	−0.579	< 0.0001	−0.613	< 0.0001	−0.598	< 0.0001
With HAQ at W54
SDAI at W6	0.392	< 0.0001	0.420	< 0.0001	0.241	0.0139
DAS28-CRP at W6	0.435	< 0.0001	0.426	< 0.0001	0.315	0.0011
SDAI at W10	0.513	< 0.0001	0.439	< 0.0001	0.280	0.0040
DAS28-CRP at W10	0.547	< 0.0001	0.432	< 0.0001	0.364	0.0001
SDAI at W14	0.455	< 0.0001	0.486	< 0.0001	0.430	< 0.0001
ΔSDAI at W14	−0.281	0.0048	−0.151	0.1252	−0.356	0.0002
Improvement, %, of SDAI at W14	−0.441	< 0.0001	−0.371	0.0001	−0.490	< 0.0001
DAS28-CRP at W14	0.486	< 0.0001	0.505	< 0.0001	0.458	< 0.0001
ΔDAS28-CRP at W14	−0.434	< 0.0001	−0.283	0.0036	−0.404	< 0.0001
Improvement, %, of DAS28-CRP at W14	−0.492	< 0.0001	−0.375	< 0.0001	−0.465	< 0.0001
With ΔTSS at W54^†
SDAI at W6^*	−0.046	0.6713	0.110	0.2956	−0.012	0.9088
DAS28-CRP at W6^*	−0.035	0.7488	0.173	0.1001	0.092	0.3756
SDAI at W10^*	0.022	0.8398	0.175	0.0956	0.021	0.8384
DAS28-CRP at W10^*	0.071	0.5133	0.170	0.1058	0.089	0.3917
SDAI at W14^*	0.096	0.3775	0.105	0.3195	0.028	0.7903
ΔSDAI at W14^*	−0.257	0.0168	−0.159	0.1300	−0.038	0.7139
Improvement, %, of SDAI at W14^*	−0.217	0.0444	−0.143	0.1743	−0.021	0.8401
DAS28-CRP at W14^*	0.115	0.2929	0.108	0.3056	0.089	0.3916
ΔDAS28-CRP at W14^*	−0.255	0.0179	−0.165	0.1151	−0.084	0.4200
Improvement, %, of DAS28-CRP at W14^*	−0.216	0.0462	−0.162	0.1225	−0.070	0.4981

Coefficients and p values were evaluated using Pearson correlation coefficient or
↵* Spearman rank correlation coefficient.
↵† n = 86, 92, and 95 in the 3 mg/kg, 6 mg/kg, and 10 mg/kg groups, respectively. W6: Week 6; W10: Week 10; W14: Week 14; HAQ: Health Assessment Questionnaire; ΔTSS: change in modified total Sharp score; W54: Week 54; SDAI: Simplified Disease Activity Index; ΔSDAI: improvement value of SDAI; DAS28-CRP: 28-joint Disease Activity Score-C-reactive protein; ΔDAS28-CRP: improvement value of DAS28-CRP.