Change from baseline in measures of disease severity for seronegative and seropositive subjects at followup.
| Measures | Seronegative, Mean (SD) | n | Seropositive, Mean (SD) | n | p |
|---|---|---|---|---|---|
| 12-mo followup | |||||
| SJC28 | −6.4 (6.9) | 139 | −4.7 (5.5) | 463 | 0.0017 |
| TJC28 | −6.7 (7.4) | 139 | −4.9 (6.4) | 463 | 0.0104 |
| ESR | −11.7 (−15.4) | 127 | −11.5 (−13.6) | 405 | 0.9302 |
| CRP, mg/l | −8.1 (18.9) | 118 | −8.4 (17.0) | 406 | 0.8392 |
| DAS28 | −2.1 (1.9) | 118 | −1.9 (1.7) | 383 | 0.2649 |
| 24-mo followup | |||||
| SJC28 | −6.9 (7.0) | 105 | −5.1 (5.9) | 334 | 0.0189 |
| TJC28 | −7.1 (8.0) | 105 | −4.3 (6.6) | 334 | 0.0017 |
| ESR | −12.7 (16.2) | 93 | −9.5 (21.9) | 304 | 0.1391 |
| CRP, mg/l | −11.0 (17.9) | 92 | −6.4 (17.5) | 308 | 0.0274 |
| DAS28 | −2.4 (2.0) | 86 | −1.8 (1.8) | 291 | 0.0152 |
SJC28: swollen joint count of 28 joints; TJC28: tender joint count of 28 joints; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; DAS28: 28-joint Disease Activity Score.