Differences in baseline clinical characteristics between 14-3-3η-negative and -positive patients with RA (combined cohorts). Except for p values, all data are median (IQR).
| 14-3-3η Negative, n = 67 | 14-3-3η Positive, n = 167 | p | |
|---|---|---|---|
| Age, yrs | 55 (48–66)67 | 58 (47–66)167 | 0.76 |
| DAS | 5.7 (4.6–6.4)44 | 6.3 (5.2–7.2)130 | 0.026 |
| HAQ | 1.0 (0.8–1.8)20 | 1.9 (1.4–2.4)91 | 0.001 |
| ESR, mm/h | 25 (14–35)43 | 38 (20–48)130 | 0.003 |
| CRP, mg/l | 9.0 (3.0–26.8)43 | 19.2 (8.0–47.4)128 | 0.006 |
| RF, IU/ml | 11.4 (10.0–40.0)54 | 43.5 (10.0–154.8)146 | 0.004 |
| ACPA, U/ml | 5.0 (2.0–20.0)36 | 489.0 (48.5–1279)62 | 0.0001 |
Superscripted numbers refer to the number of patients within the group. RA: rheumatoid arthritis; IQR: interquartile range; DAS: Disease Activity Score; HAQ: Health Assessment Questionnaire; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; RF: rheumatoid factor; ACPA: anticitrullinated protein antibodies.