Table 2.

The use of NSAID in the 6 months prior to and the 6 months following new initiation of TNFi use.

No. NSAID Users No. Prior to New TNFi UseNSAID Users Following New TNFi UsepMean No. NSAID Prescriptions Prior to New TNFi Use (SD)Mean No. NSAID Prescriptions Following New TNFi Use (SD)Mean Change in No. NSAID Prescriptions (95% CI)p
All new TNFi users, n = 344194 (56%)149 (43%)0.00061.6 (1.9)1.2 (1.8)−0.4 (0.2–0.6)0.0003
Prevalent NSAID users, n = 194194 (100%)125 (64%)< 0.00012.8 (1.7)2.0 (2.0)−0.9 (0.5–1.2)< 0.0001
  • NSAID: nonsteroidal antiinflammatory drugs; TNFi: tumor necrosis factor inhibitors.