The use of NSAID in the 6 months prior to and the 6 months following new initiation of TNFi use.
| No. NSAID Users No. Prior to New TNFi Use | NSAID Users Following New TNFi Use | p | Mean No. NSAID Prescriptions Prior to New TNFi Use (SD) | Mean No. NSAID Prescriptions Following New TNFi Use (SD) | Mean Change in No. NSAID Prescriptions (95% CI) | p | |
|---|---|---|---|---|---|---|---|
| All new TNFi users, n = 344 | 194 (56%) | 149 (43%) | 0.0006 | 1.6 (1.9) | 1.2 (1.8) | −0.4 (0.2–0.6) | 0.0003 |
| Prevalent NSAID users, n = 194 | 194 (100%) | 125 (64%) | < 0.0001 | 2.8 (1.7) | 2.0 (2.0) | −0.9 (0.5–1.2) | < 0.0001 |
NSAID: nonsteroidal antiinflammatory drugs; TNFi: tumor necrosis factor inhibitors.