Table 1.

Demographic and clinical features, menstrual cycles, obstetric data, and ovarian reserve in patients with TA and healthy controls. Values are expressed in n (%), mean ± SD, or median (range). Gynecologic age is time between menarche and current age.

VariablesTA, n = 20Controls, n = 24p
Demographic and clinical features
  Current age, yrs31.2 ± 6.130.4 ± 6.90.69
  BMI, kg/m224.2 ± 4.624.9 ± 4.50.61
  Arterial hypertension11 (55)1 (4)0.0003***
  White16 (80)13 (54)0.11
  Socio-economic class C or D16 (80)15 (58)0.19
Menstrual cycles
  Age at menarche, yrs13 (9–16)12 (11–18)0.49
  Gynecologic age, yrs18.8 ± 6.717.8 ± 6.70.63
  Any menstrual disturbances10 (50)7 (29)0.21
    Amenorrhea1 (5)0 (0)0.45
    Flow duration, days4.5 (0–8)5 (2–10)0.25
      < 33 (15)1 (4)0.31
      > 72 (10)3 (12.5)1.0
    Cycle length, days30 (0–35)30 (15–40)0.85
      < 244 (20)1 (4)0.16
      > 350 (0)2 (8)0.49
Obstetric data
  Nulliparity9 (45)13 (54)0.76
  Number of live births1 (0–3)0 (0–2)0.28
  Abortion0 (0–2)0 (0–2)0.34
Ovarian reserve
  FSH, IU/l6.8 ± 2.76.5 ± 2.60.69
    Elevated levels (> 10 IU/1)1 (5)2 (8)1.0
  LH, IU/l4 (2.4–9.3)5 (2.1–10.6)0.79
  Estradiol, pg/ml41.5 (23–91)34 (24–128)0.44
  AMH Gen II, ng/ml0.7 (0.2–3.5)2.7 (0.1–6.6)0.008***
    Decreased levels (< 1 ng/ml)10 (50)4 (17)0.02***
  AMH AnshLabs, ng/ml*1.0 (0.1–4.6)2.3 (0–6.6)0.12
    Decreased levels (< 1 ng/ml)10 (50)4 (19)0.048***
  Ovarian volumes, mm3**5.4 (2–14.1)5.2 (1.4–17.3)0.79
  AFC**11 (3–40)16 (5–37)0.13
    Low AFC (≤ 10)7 (41)5 (22)0.29
    Very low (≤ 5)2 (12)2 (9)1.0

  • ↵* n = 20 patients with TA and 22 controls.

  • ↵** n = 17 TA patients and 23 controls.

  • ↵*** Significant data. TA: Takayasu arteritis; BMI: body mass index; FSH: follicle-stimulating hormone; LH: luteinizing hormone; AMH: anti-Müllerian hormone; AFC: antral follicle count.