Table 4.

Comparison of sites of first gout attack.

Site	Early-onset Gout with Tophi, n = 40 (%)	Early-onset Gout without Tophi, n = 47 (%)	Middle-Age-Onset Gout with Tophi, n = 353 (%)	p¹	p²
Toe	13 (32.5)	16 (34.0)	125 (35.4)	0.879	0.715
Midfoot	3 (7.5)	2 (4.3)	48 (13.6)	0.517	0.277
Ankle	15 (37.5)	24 (51.1)	117 (33.1)	0.205	0.580
Achilles	5 (12.5)	0 (0.0)	4 (1.1)	0.013	< 0.0001
Knee	1 (2.5)	4 (8.5)	41 (11.6)	0.230	0.077
Finger	2 (5.0)	0 (0.0)	9 (2.5)	0.121	0.373
Wrist	0 (0.0)	0 (0.0)	5 (1.4)	—	0.449
Elbow	1 (2.5)	1 (2.1)	4 (1.1)	0.908	0.465

Chi-square tests used to determine level of statistical significance.
↵1 Comparison between early-onset gout patients with and without tophi.
↵2 Comparison between early-onset and middle-age-onset tophaceous gout patients.