Table 3.

Effect of BP variability on cardiovascular (CV) events and all-cause mortality in rheumatoid arthritis (RA). Patients with a CV event before RA were excluded from the analyses because they were not at risk of developing that CV event during followup.

Variable	HR (95% CI)^*, Adjusted for Age, Sex, and Calendar Year of RA Incidence		HR (95% CI)^, Adjusted for Age, Sex, and Calendar Year of RA Incidence, and CV Risk Factors^*
Variable	CV events	All-cause Mortality	CV Events	All-cause Mortality
Systolic BP variability	1.14 (1.04–1.25)	1.10 (1.03–1.17)	1.12 (1.01–1.25)	1.04 (0.97–1.12)
Diastolic BP variability	1.15 (1.02–1.30)	1.22 (1.11–1.34)	1.11 (0.95–1.28)	1.14 (1.03–1.27)
Pulse pressure variability	1.10 (0.98–1.24)	1.11 (1.02–1.22)	1.09 (0.96–1.23)	1.06 (0.97–1.17)

↵* HR per 1 mm Hg increase in BP variability.
↵** Adjusting for systolic and diastolic BP, BMI, smoking at index date, and for time-dependent covariates (i.e., diabetes, dyslipidemia, use of antihypertensives). BP: blood pressure.