Cox regression of risk factors for tuberculosis (TB) in the systemic sclerosis (SSc) cohort.
| Variables | Univariate Analysis | Multivariable Analysisa | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Age ≥ 60 yrs | 4.13 (1.31–13.02) | 0.016 | 3.52 (1.10–11.33) | 0.035 |
| Male sex | 1.21 (0.33–4.48) | 0.775 | ||
| Comorbidity | ||||
| Hypertension | 2.06 (0.66–6.51) | 0.216 | ||
| COPD | 2.44 (0.77–7.68) | 0.129 | ||
| Chronic kidney disease | 0.96 (0.21–4.38) | 0.957 | ||
| SSc with pulmonary involvement | ||||
| Pulmonary hypertension | 9.65 (2.58–36.11) | 0.001 | 6.06 (1.59–23.17) | 0.008 |
| Interstitial lung disease | 3.02 (0.82–11.17) | 0.097 | ||
| Medications, ≥ 28 cDDD | ||||
| Corticosteroid | 7.94 (1.02–61.50) | 0.047 | 7.07 (0.91–55.12) | 0.062 |
| Cyclophosphamide | 4.23 (1.27–14.06) | 0.019 | 2.63 (0.78–8.87) | 0.119 |
| Cyclosporine | 0.05 (0.00–6.372E8) | 0.800 | ||
| Methotrexate | 2.18 (0.28–16.90) | 0.456 | ||
| Azathioprine | 3.42 (0.75–15.60) | 0.113 | ||
↵a All factors with p < 0.1 in univariate analyses were included in the multivariable Cox regression. cDDD: cumulative defined daily dose; HR: hazard ratio; COPD: chronic obstructive pulmonary disease.