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Oral ulcer — the presence of an oral ulcer not known to be infectious in origin -
Genital ulcer — the presence of a genital ulcer not known to be infectious in origin -
Skin disease — acneiform lesions, pustular skin disease, or nodular disease -
Arthralgia — the presence of joint pain with or without arthritis on exam -
Eye disease — uveitis or retinal vasculitis -
Gastrointestinal disease — documented presence of a gastrointestinal ulcer on endoscopy. The usage of nonsteroidal antiinflammatory (NSAID) medications was not an exclusion to endoscopy; however, patients were asked to hold NSAID for a minimum of 4 weeks at the US National Institutes of Health and 3 months at the University of Istanbul -
Neurologic disease — dural sinus thrombosis or white matter changes on radiographic studies in the setting of clinical neurologic symptoms other than headaches -
Thrombosis — deep vein or arterial thrombosis on exam or radiographic studies
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