APPENDIX 1.

Definitions of Organ Involvement in Behçet syndrome.

  1. Oral ulcer — the presence of an oral ulcer not known to be infectious in origin

  2. Genital ulcer — the presence of a genital ulcer not known to be infectious in origin

  3. Skin disease — acneiform lesions, pustular skin disease, or nodular disease

  4. Arthralgia — the presence of joint pain with or without arthritis on exam

  5. Eye disease — uveitis or retinal vasculitis

  6. Gastrointestinal disease — documented presence of a gastrointestinal ulcer on endoscopy. The usage of nonsteroidal antiinflammatory (NSAID) medications was not an exclusion to endoscopy; however, patients were asked to hold NSAID for a minimum of 4 weeks at the US National Institutes of Health and 3 months at the University of Istanbul

  7. Neurologic disease — dural sinus thrombosis or white matter changes on radiographic studies in the setting of clinical neurologic symptoms other than headaches

  8. Thrombosis — deep vein or arterial thrombosis on exam or radiographic studies