Table 1.

Demographic, laboratory, and clinical characteristics of 183 patients with ANCA-associated vasculitis and ANCA positivity measured by ELISA.

PR3-ANCA, n = 98MPO-ANCA, n = 85p
Sex, F/M39/5948/370.024
Diagnosis: GPA/MPA/EGPA73/25/017/64/4
Age at diagnosis, yrs63.2 ± 15.968.7 ± 14.40.016
Diagnosis delay, mos2 (1–4)2 (1–5)0.063
Laboratory results
  C-reactive protein, mg/dl11.65 (6.5–19.1)3.4 (0.9–12.4)< 0.001
  ESR, mm/h77 ± 3058 ± 350.004
  Hemoglobin, g/dl11.1 ± 1.8210.6 ± 1.770.004
  Thrombocyte count, × 109/l408 (333–517)324 (261–400)< 0.001
  White blood cell count, × 109/l11.9 (9.9–15)9.6 (7.1–13)0.002
  Creatinine, mg/dl1.46 (0.81–3.03)2.67 (1.21–5.19)0.004
Patients with ≥ 3 organ systems involved, n (%)75 (76)48 (56)0.004
Deaths during followup, n (%)36 (37)36 (42)0.438
Organ systems involved at diagnosis
  General, n (%)92 (94)72 (85)0.042
  ENT, n (%)58 (59)16 (19)< 0.001
  Chest, n (%)51 (52)34 (40)0.103
  Nervous, n (%)14 (14)8 (9)0.312
  Cutaneous, n (%)5 (5)6 (7)0.579
  Mucocutaneous and eyes, n (%)10 (10)2 (2)0.032
  Cardiovascular, n (%)4 (4)4 (5)0.837
  Abdominal, n (%)5 (5)8 (9)0.258
  Renal, n (%)67 (68)72 (85)0.01
  • Results are mean ± SD (normally distributed variables) or median and interquartile range (not normally distributed variables), or number and percentage. GPA: granulomatosis with polyangiitis (formerly Wegener); MPA: microscopic polyangiitis; EGPA: eosinophilic granulomatosis with polyangiitis (Churg-Strauss); ENT: ear-nose-throat; ESR: erythrocyte sedimentation rate; ANCA: antineutrophil cytoplasmic antibody; PR3: proteinase 3; MPO: myeloperoxidase.