Characteristics of infusion reactions (IR).
| Characteristics | All Patients, n = 82; All Infusions, n = 2446 | All Patients with IR, n = 14 | All Infusions, n = 2446 |
|---|---|---|---|
| Patients with IR, n (%) | 14 (17) | 14 (100) | |
| No. patients with IR/100 patient-yrs | 5.1 | ||
| IR, n (%) | 46 (2) | 46 (100) | |
| IR/100 patient-yrs | 16.9 | ||
| Severity of IR, n (%) | |||
| Mild | 12 (26) | 6 (43) | 12 (26) |
| Moderate | 34 (74) | 11 (79) | 34 (74) |
| Severe | 0 | 0 | |
| Symptoms during IR, n (%) | |||
| Respiratory | 33 (72) | 10 (71) | 33 (72) |
| Dyspnea | 22 (48) | 7 (50) | 22 (48) |
| Cough | 19 (41) | 7 (50) | 19 (41) |
| Wheezing | 5 (11) | 4 (29) | 5 (11) |
| Malaise | 28 (61) | 12 (86) | 28 (61) |
| Cutaneous (flush, rash) | 27 (59) | 8 (57) | 27 (59) |
| Gastrointestinal | 6 (13) | 5 (36) | 6 (13) |
| Abdominal pain | 1 (2) | 1 (7) | 1 (2) |
| Diarrhea and vomiting | 5 (11) | 4 (29) | 5 (11) |
| Hypotonia/tachycardia | 0 | 0 | 0 |
| Treatment during IR, n (%) | |||
| Antihistamine IV (clemastine) | 39 (85) | 13 (93) | 39 (85) |
| Corticosteroid IV (methylprednisolone) | 22 (48) | 10 (71) | 22 (48) |
| Epinephrine inhalation | 6 (13) | 2 (14) | 6 (13) |
| Albuterol inhalation | 1 (2) | 1 (7) | 1 (2) |
IV: intravenous.