Table 3.

The use of serological status to predict remission at 24 months using 3-drug therapy (methotrexate, cyclosporine, and prednisolone) compared to methotrexate monotherapy. Adjusted for treatment region, baseline DAS28, sex, and age.

Predictors of ResponseOR95% CIp
RF-IgM–negative1.170.58, 23.9NS
RF-IgM–positive2.541.12, 5.760.026
ACPA-negative0.910.19, 4.28NS
ACPA-positive3.521.37, 9.030.009
  • DAS28: 28-joint Disease Activity Score; RF-IgM: rheumatoid factor–IgM isotype; ACPA: anticitrullinated protein antibodies; NS: not significant.