Patients with AS, n = 204, Median (range) | Controls, n = 80, Median (range) | p | |
---|---|---|---|
Sex, female/male | 87/117 | 26/54 | 0.100 |
Age, yrs | 49 (17, 78) | 48 (19, 71) | 0.202 |
Wnt-3a, ng/ml | 3.66 (0.99, 7.98) | 2.78 (1.50, 5.10) | < 0.001 |
DKK-1, ng/ml | 2.89 (1.14, 7.11) | 2.66 (0.85, 6.10) | 0.058 |
Sclerostin, pmol/l | 31.88 (0, 173.48) | 36.96 (0, 85.52) | 0.014 |
sRANKL, pmol/l | 165.23 (14.96, 2875.39) | 210.80 (21.49, 1671.53) | 0.047 |
OPG, pmol/l | 3.62 (1.62, 7.63) | 3.46 (0, 6.32) | 0.264 |
sRANKL/OPG, ratio | 45.55 (4.44, 1020.00) | 68.49 (4.50, 671.01) | 0.022 |
DKK-1: Dickkopf-1; OPG: osteoprotegerin; sRANKL: soluble receptor activator of nuclear factor-κB ligand; Wnt: wingless protein.