Allelic frequencies in patients with AOSD and healthy controls. Differences (p) were calculated with chi-square or Fisher’s exact test.
| Protein Name | Sequence Change | rs No. | MAF AOSD | MAF Controls | p | OR (95% CI) |
|---|---|---|---|---|---|---|
| NLRP3 | ||||||
| p.Ala242Ala | c.726G > A | rs3806268 | 0.472 | 0.453 | 0.8164 | 1.0826 (0.5541–2.1151) |
| p.Thr219Thr | c.657C > T | rs7525979 | 0.055 | 0.059 | 1.0000 | 0.9320 (0.2170–4.0035) |
| p.Ser434Ser | c.1302C > T | rs34298354 | 0.083 | 0.112 | 0.7880 | 0.7198 (0.2161–2.3975) |
| p.Arg260Arg | c.780G > A | rs4925543 | 0.055 | 0.044 | 0.6693 | 1.2923 (0.2977–5.6102) |
| p.Gln703Lys | c.2107C > A | rs35829419 | 0.027 | 0.041 | 1.0000 | 0.6700 (0.0889–5.0510) |
| p.Pro340Pro | c.1020C > T | rs41311573 | 0.027 | 0.011 | 0.3428 | 2.6786 (0.3259–22.0120) |
| p.Val198Met | c.592G > A | rs121908147 | 0.027 | 0.013 | 0.4017 | 2.1371 (0.2661–17.1647) |
| NOD2 | ||||||
| p.Pro268Ser | c.802C > T | rs2066842 | 0.333 | 0.243 | 0.2181 | 1.5598 (0.7649–3.1807) |
| p.Arg459Arg | c.1377C > T | rs2066843 | 0.333 | 0.243 | 0.2181 | 1.5598 (0.7649–3.1807) |
| p.Arg587Arg | c.1761T > G | rs1861759 | 0.305 | 0.423 | 0.1610 | 0.5990 (0.2905–1.2351) |
| p.Arg702Trp | c.2104C > T | rs2066844 | 0.055 | 0.051 | 0.7085 | 1.0845 (0.2513–4.6792) |
| p.Arg791Gln | c.2372G > A | rs104895464 | 0.027 | 0.001 | 0.0887 | 21.6286 (1.3252–352.9972)* |
↵* p < 0.05. AOSD: Adult-onset Still’s disease; MAF: minor allele frequency.