Patient outcomes for treatment groups.
| Patient Outcomes | Never Taking Therapy, n = 11,192 | < 80% Time Taking Therapy, n = 3902 | ≥ 80% Time Taking Therapy, n = 1092 | Total Patients, n = 16,186 | p |
|---|---|---|---|---|---|
| Primary outcome, n (%) | 350 (3.1) | 188 (4.8) | 42 (3.8) | 580 (3.6) | < 0.0001* |
| Primary outcome category, n (%) | n = 350 | n = 188 | n = 42 | n = 580 | 0.33* |
| 30% reduction in GFR level from baseline | 347 (99.1) | 185 (98.4) | 42 (100) | 574 (99) | |
| GFR level < 15 ml/min/1.72 m2 or dialysis | 3 (0.9) | 3 (1.6) | 0 (0) | 6 (1) | |
| Median followup, days | 812 | 885 | 822 | 831 | |
| Development of other outcomes, n (%) | n = 11,192 | n = 3902 | n = 1092 | n = 16,186 | < 0.0001* |
| Development of cancer | 40 (0.4) | 24 (0.6) | 4 (0.4) | 68 (0.4) | |
| Death | 146 (1.3) | 42 (1.1) | 9 (0.8) | 197 (1.2) | |
| Glomerular nephritis | 813 (7.3) | 348 (8.9) | 135 (12.4) | 1296 (8) | |
| Other transplant | 10 (0.1) | 1 (0) | 1 (0.1) | 12 (0.1) | |
| No outcomes | 10176 (90.9) | 3485 (89.3) | 940 (86.1) | 14601 (90.2) | |
| sUA level | n = 11,192 | n = 3902 | n = 1092 | n = 16,186 | |
| sUA level, mg/dl, at baseline | 8.1 (1.02) | 8.9 (1.30) | 9.2 (1.43) | 8.3 (1.20) | < 0.0001** |
| sUA level, mg/dl, mean (SD) last value | 7.2 (1.58) | 7.2 (1.76) | 6.0 (1.40) | 7.1 (1.64) | < 0.0001** |
| Net decrease in sUA | 0.9 (1.59) | 1.7 (1.98) | 3.1 (1.78) | 1.2 (1.82) | < 0.0001** |
| At goal, < 6 mg/dl, n (%) | 2447 (21.9) | 1088 (27.9) | 584 (53.5) | 4119 (25.4) | < 0.0001** |