Baseline and 12-month characteristics of concordance and higher PGA groups in the 3 models. Data are expressed as mean (SD) unless otherwise indicated. The numbers for current treatments include combination therapy use.
| Discordance Model | 5 mm | 10 mm | 20 mm | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Concordance, n = 29 | PGA Higher, n = 38 | p | Concordance, n = 38 | PGA Higher, n = 34 | p | Concordance, n = 48 | PGA Higher, n = 24 | p | |
| At baseline | |||||||||
| Age, yrs | 62.5 (13.3) | 57.1 (14.5) | 0.12 | 62.6 (12.5) | 57.2 (15.1) | 0.10 | 61.9 (13.6) | 56.4 (14.3) | 0.13 |
| Duration, mos | 9.4 (14.5) | 10.2 (20.6) | 0.85 | 9.9 (22.2) | 7.7 (9.9) | 0.38 | 9.5 (20.0) | 9.5 (11.3) | 1.00 |
| Smoking, n (%) | 5 (24) | 14 (37) | 0.38 | 9 (24) | 10 (35) | 0.57 | 14 (29) | 7 (29) | 1.00 |
| SE, n (%) | 19 (66) | 24 (63) | 0.90 | 24 (63) | 22 (65) | 0.93 | 32 (67) | 14 (58) | 0.64 |
| Anti-CCP, n (%) | 18 (64) | 21 (55) | 0.40 | 25 (66) | 18 (52) | 0.16 | 30 (61) | 13 (56) | 0.61 |
| DAS28 | 4.3 (1.2) | 4.6 (1.1) | 0.32 | 4.4 (1.1) | 4.7 (1.1) | 0.23 | 4.4 (1.2) | 4.6 (1.0) | 0.64 |
| SDAI | 15.3 (10.1) | 16.9 (10.6) | 0.54 | 16.2 (10.3) | 17.2 (10.9) | 0.68 | 17.0 (11.4) | 16.0 (8.9) | 0.66 |
| CDAI | 13.3 (8.7) | 15.0 (9.2) | 0.45 | 14.4 (9.3) | 15.2 (9.5) | 0.73 | 15.1 (10.0) | 14.2 (7.8) | 0.67 |
| SJC | 3.2 (2.8) | 3.8 (3.7) | 0.43 | 4.0 (3.5) | 3.8 (3.7) | 0.9 | 4.1 (3.9) | 3.5 (3.0) | 0.50 |
| TJC | 2.6 (2.9) | 3.1 (3.4) | 0.56 | 3.2 (3.2) | 3.2 (3.5) | 1.0 | 3.3 (3.7) | 2.9 (3.1) | 0.58 |
| PGA, mm | 42.6 (33.4) | 42.9 (24.2) | 0.97 | 40.7 (31.4) | 43.6 (23.4) | 0.67 | 42.4 (30.4) | 41.5 (22.0) | 0.89 |
| Pain VAS, mm | 42.8 (33.3) | 43.7 (24.5) | 0.90 | 41.3 (31.9) | 44.7 (24.5) | 0.61 | 44.0 (30.0) | 40.8 (25.6) | 0.65 |
| EGA, mm | 32.4 (24.1) | 37.9 (21.3) | 0.33 | 32.4 (23.7) | 38.2 (20.8) | 0.27 | 34.5 (24.4) | 36.3 (18.0) | 0.73 |
| CRP, mg/dl | 2.0 (2.9) | 1.9 (2.1) | 0.90 | 1.8 (2.6) | 2.1 (2.2) | 0.63 | 2.0 (2.7) | 1.8 (2.0) | 0.78 |
| ESR, mm/h | 56.7 (36.4) | 60.6 (34.0) | 0.65 | 51.4 (34.5) | 61.5 (33.7) | 0.11 | 54.2 (34.3) | 64.3 (34.8) | 0.25 |
| HAQ | 0.63 (0.75) | 0.84 (0.70) | 0.23 | 0.66 (0.75) | 0.84 (0.63) | 0.29 | 0.77 (0.80) | 0.69 (0.49) | 0.60 |
| TSS | 6.6 (7.0) | 9.6 (20.5) | 0.36 | 6.3 (7.0) | 9.9 (21.4) | 0.34 | 5.4 (6.5) | 13.2 (24.9) | 0.15 |
| At 12 mos | |||||||||
| DAS28 | 2.3 (0.8) | 3.0 (1.1) | < 0.01 | 2.3 (0.79) | 3.1 (1.1) | < 0.01 | 2.3 (0.8) | 3.3 (1.0) | < 0.01 |
| SDAI | 2.8 (5.1) | 7.1 (5.1) | < 0.01 | 3.0 (4.6) | 7.5 (5.2) | < 0.01 | 3.3 (4.5) | 3.3 (4.5) | < 0.01 |
| CDAI | 2.7 (5.0) | 6.8 (5.0) | < 0.01 | 2.85 (4.5) | 7.3 (5.1) | < 0.01 | 3.1 (4.4) | 8.5 (4.9) | < 0.01 |
| SJC | 0.8 (2.0) | 1.3 (1.8) | 0.30 | 0.8 (1.8) | 1.3 (1.9) | 0.16 | 0.7 (1.6) | 1.8 (2.0) | 0.04 |
| TJC | 0.2 (0.6) | 1.0 (1.8) | 0.01 | 0.3 (0.8) | 1.0 (1.8) | 0.04 | 0.3 (0.8) | 1.3 (2.0) | 0.04 |
| PGA, mm | 8.7 (17.0) | 37.1 (21.0) | < 0.01 | 8.8 (15.2) | 40.1 (20.2) | < 0.01 | 12.1 (16.5) | 46.6 (18.9) | < 0.01 |
| Pain VAS, mm | 8.7 (16.3) | 30.0 (23.2) | < 0.01 | 8.5 (14.5) | 32.2 (23.6) | < 0.01 | 11.0 (17.1) | 37.0 (22.3) | < 0.01 |
| EGA, mm | 8.2 (17.3) | 8.3 (10.0) | 0.98 | 8.7 (15.8) | 8.8 (10.4) | 0.98 | 8.7 (15.2) | 8.8 (9.0) | 0.96 |
| CRP, mg/dl | 0.1 (0.2) | 0.3 (0.3) | 0.06 | 0.2 (0.2) | 0.3 (0.3) | 0.16 | 0.2 (0.2) | 0.3 (0.4) | 0.23 |
| ESR, mm/h | 21.6 (18.7) | 24.7 (22.2) | 0.54 | 20.7 (17.5) | 26.1 (22.9) | 0.28 | 21.2 (18.7) | 27.3 (23.0) | 0.27 |
| HAQ | 0.26 (0.56) | 0.58 (0.46) | 0.01 | 0.25 (0.50) | 0.61 (0.46) | < 0.01 | 0.29 (0.50) | 0.67 (0.45) | < 0.01 |
| ØTSS, n (%) | 2.4 (6.7) | 5.1 (9.2) | 0.17 | 2.4 (6.3) | 7.9 (12.8) | 0.05 | 2.6 (6.0) | 8.2 (14.8) | 0.09 |
| ≤ 0.5 (sREM) | 17 (59) | 15 (39) | 24 (63) | 12 (35) | 29 (60) | 7 (29) | |||
| 0.5 to 5 | 7 (25) | 10 (27) | 0.22 | 8 (21) | 9 (27) | 0.04 | 10 (21) | 7 (29) | 0.03 |
| ≥ 5 (RRP) | 5 (17) | 13 (34) | 6 (16) | 13 (38) | 9 (19) | 10 (42) | |||
| Current tx, n (%) | |||||||||
| MTX | 17 (59) | 24 (63) | 0.90 | 24 (63) | 21 (62) | 0.90 | 31 (65) | 14 (58) | 0.80 |
| Steroid | 2 (7) | 3 (8) | 0.88 | 3 (8) | 3 (9) | 0.89 | 3 (6) | 3 (13) | 0.65 |
| Biologic | 5 (17) | 10 (26) | 0.56 | 6 (16) | 9 (26) | 0.41 | 10 (21) | 5 (21) | 1.00 |
| Others | 14 (48) | 16 (42) | 0.80 | 17 (45) | 15 (44) | 0.96 | 20 (42) | 12 (50) | 0.68 |
P values in italics are considered significant. SE: shared epitope; anti-CCP: anticyclic citrullinated peptide antibody; DAS28: 28-joint Disease Activity Score; SDAI: Simplified Disease Activity Score; CDAI: Clinical Disease Activity Score; TJC: tender joint count; SJC: swollen joint count; PGA: patient global assessment; VAS: visual analog scale; EGA: evaluator global assessment; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; MMP: matrix metalloproteinase; HAQ: Health Assessment Questionnaire; TSS: van der Heijde/modified total Sharp score; sREM: structural remission (ØTSS ≤ 0.5/yr); RRP: rapid radiographic progression (ØTSS ≥ 5/yr); tx: treatment; MTX: methotrexate.