Multivariable predictors of treatment resistance and relapse.
| Predictor | Predictors of treatment resistance, n = 98* | Predictors of relapse, n = 74† | ||
|---|---|---|---|---|
| OR (95% CI)‡ | p‡ | Hazard Ratio (95% CI)‡ | p‡ | |
| Female vs male | 2.85 (1.06, 2.86) | 0.036 | 0.72 (0.65, 6.87) | 0.18 |
| Age per 20 yrs | 1.35 (0.43, 3.45) | 0.99 | 1.45 (0.97, 3.59) | 0.08 |
| PR3 ANCA vs MPO ANCA | 0.66 (0.11, 7.26) | 0.86 | 1.31 (1.01, 5.35) | 0.0001 |
| GPA vs MPA | 4.87 (0.63, 6.36) | 0.52 | 0.81 (0.55, 3.27) | 0.31 |
| Lung involvement | 0.52 (0.18, 3.28) | 0.49 | 1.87 (1.12, 4.35) | 0.014 |
| Upper respiratory involvement | 0.55 (0.12, 2.93) | 0.85 | 1.01 (0.25, 2.33) | 0.66 |
| Serum creatinine (per 150 μmol/l)# | 5.27 (1.29, 6.34) | 0.002 | 0.89 (0.73, 3.56) | 0.39 |
↵* Estimated using logistic regression.
↵† Estimated using cause-specific proportional hazard models.
↵‡ Evaluated in a model that controlled for all other measures identified by backward selection.
↵# Peak serum creatinine level at diagnosis. ANCA: antineutrophil cytoplasmic antibody; PR3: proteinase 3; MPO: myeloperoxidase; GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis.