Cox proportional hazard regression analysis for the risk of Sjögren syndrome-associated DVT and PE with interaction of comorbidity.
| Variables | Interaction | N | Events, n | Adjusted HR† (95% CI) | p& | |
|---|---|---|---|---|---|---|
| DVT | Sjögren syndrome | Comorbidity‡ | 0.05 | |||
| No | No | 33,340 | 44 | 1 (Reference) | ||
| No | Yes | 2340 | 16 | 1.52 (0.80, 2.89) | ||
| Yes | No | 8377 | 21 | 1.68 (0.99, 2.83) | ||
| Yes | Yes | 543 | 7 | 3.66 (2.61, 8.33)** | ||
| PE | 0.05 | |||||
| Sjögren syndrome | Comorbidity‡ | |||||
| No | No | 33,340 | 24 | 1 (Reference) | ||
| No | Yes | 2340 | 14 | 4.12 (2.06, 8.24)*** | ||
| Yes | No | 8377 | 22 | 3.59 (2.01, 6.41)*** | ||
| Yes | Yes | 543 | 8 | 11.4 (5.12, 25.2)*** | ||
↵† Adjusted for age, sex, and frequency of admission visits.
↵** p < 0.01.
↵*** p < 0.001.
↵& p value for interaction.
↵‡ Any of the comorbidities including atrial fibrillation, diabetes, CVA, heart failure, lower leg fracture or surgery, cancer, and pregnancy. DVT: deep vein thrombosis; PE: pulmonary embolism; HR: hazard ratio; CVA: cerebrovascular disease.