APPENDIX 2.

Extrarenal manifestations by systems in responders and nonresponder patients at baseline visit and end of study.

SLEDAI-2K Organ SystemsResponders, n = 128, n (%)Nonresponders, n = 84, n (%)p
CNS
  at start18 (14.1)9 (10.7)0.47
  at end5 (3.9)7 (8.3)0.23
Vascular
  at start13 (10.2)7 (8.3)0.66
  at end3 (2.3)3 (3.6)0.68
Musculoskeletal
  at start15 (11.7)6 (7.1)0.28
  at end3 (2.3)1 (1.2)1.00
Serosal
  at start16 (12.5)5 (6.0)0.12
  at end0 (0)4 (4.8)0.02
Dermal
  at start47 (36.7)34 (40.5)0.58
  at end31 (24.2)20 (23.8)0.95
Immunologic
  at start103 (81.1)71 (84.5)0.52
  at end76 (59.4)54 (65.1)0.41
Constitutional
  at start22 (17.3)5 (6.0)0.02
  at end3 (2.3)7 (8.3)0.05
Hematologic
  at start6 (4.7)3 (3.6)1.00
  at end1 (0.8)8 (9.5)0.003
  • SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index-2000; CNS: central nervous system.