Minimum clinically important difference (MCID) and moderate improvement thresholds in patients with symptoms of knee osteoarthritis (OA).
| Improvement in Score, Mean (SD) | Relative % Improvement in Score | MDC90 | |
|---|---|---|---|
| ICOAP pain (scale 0–100) | |||
| Moderate improvement (“great deal better”), n = 12 | −26.7 (± 14.8) | −60.5 | 49.6 |
| MCID improvement (“somewhat better”), n = 26 | −18.5 (± 22.0) | −31.0 | 46.6 |
| ICOAP constant pain | |||
| Moderate improvement (“great deal better”), n = 12 | −29.6 (± 14.8) | −68.3 | 53.8 |
| MCID improvement (“somewhat better”), n = 26 | −18.7 (± 24.4) | −32.7 | 49.6 |
| ICOAP intermittent pain | |||
| Moderate improvement (“great deal better”), n = 12 | −24.3 (± 17.9) | −54.3 | 48.7 |
| MCID improvement (“somewhat better”), n = 26 | −18.4 (± 25.4) | −29.7 | 50.8 |
| KOOS-PS (scale 0–100) | |||
| Moderate improvement (“great deal better”), n = 12 | −15.0 (± 16.4) | −32.3 | 35.5 |
| MCID improvement (“somewhat better”), n = 26 | −2.2 (± 17.5) | −4.0 | 28.3 |
| KOOS-QOL (scale 0–100) | |||
| Moderate improvement (“great deal better”), n = 12 | 15.6 (± 18.8) | 35.7 | 39.0 |
| MCID improvement (“somewhat better”), n = 25 | 8.0 (± 16.1) | 25.7 | 29.0 |
Relative % improvement in score was calculated as = 100 (followup score mean–baseline score mean)/baseline score mean. ICOAP: intermittent and constant OA pain score; KOOS-PS: Knee injury and OA Outcome Score Physical function Short-form; QOL: quality of life; MDC: minimal detectable change.