Model 1 | Model 2 | |||
---|---|---|---|---|
Characteristics | Partial R | p | Partial R | p |
Endothelial activation molecules | ||||
E-selectin | 0.08 (−0.29 to 0.45) | 0.7 | 0.12 (−0.25 to 0.48) | 0.5 |
P-selectin* | 0.17 (−0.20 to 0.54) | 0.3 | 0.24 (−0.13 to 0.60) | 0.2 |
VCAM-1 | −0.02 (−0.35 to 0.32) | 0.9 | 0.04 (−0.31 to 0.37) | 0.8 |
ICAM-1* | 0.38 (0.03 to 0.72) | 0.03† | 0.41 (0.07 to 0.75) | 0.02† |
ICAM-3* | 0.16 (−0.21 to 0.53) | 0.4 | 0.18 (−0.18 to 0.55) | 0.3 |
Carotid atherosclerosis | ||||
Intima-media thickness* | 0.53 (0.16 to 0.89) | 0.007† | 0.50 (0.13 to 0.88) | 0.01† |
OR (95% CI) | p | OR (95% CI) | p | |
Plaque | 1.52 (0.98–2.36) | 0.05† | 1.42 (0.93–2.16) | 0.09 |
OPG-endothelial activation and OPG-atherosclerosis relations were assessed in mixed regression models with adjustment for the log Framingham score and log C-reactive protein concentrations in model 1 and the log Framingham score and disease activity score in 28 joints in model 2.
↵† Statistically significant associations.
↵* Characteristics that were non-normally distributed and were logarithmically transformed prior to entering them in linear regression models. VCAM: vascular cell adhesion molecule; ICAM: intercellular adhesion molecule.