Independent relationships of osteoprotegerin (OPG) concentrations at time 0 minutes with endothelial activation at time 0 minutes and atherosclerosis in patients with rheumatoid arthritis.
| Model 1 | Model 2 | |||
|---|---|---|---|---|
| Characteristics | Partial R | p | Partial R | p |
| Endothelial activation molecules | ||||
| E-selectin | −0.01 (−0.38 to 0.36) | 1.0 | 0.02 (−0.34 to 0.40) | 0.9 |
| P-selectin* | 0.18 (−0.18 to 0.54) | 0.3 | 0.23 (−0.13 to 0.60) | 0.2 |
| VCAM-1 | 0.31 (−0.04 to 0.65) | 0.08 | 0.36 (0.01 to 0.70) | 0.04† |
| ICAM-1* | 0.34 (−0.01 to 0.69) | 0.05† | 0.34 (−0.01 to 0.69) | 0.05† |
| ICAM-3 | 0.15 (−0.22 to 0.52) | 0.4 | 0.16 (−0.21 to 0.53) | 0.4 |
| Carotid atherosclerosis | ||||
| Intima-media thickness* | 0.52 (0.15 to 0.85) | 0.008† | 0.51 (0.13 to 0.88) | 0.009† |
| OR (95% CI) | p | OR (95% CI) | p | |
| Plaque | 1.61 (1.03–2.51) | 0.03† | 1.52 (1.01–2.29) | 0.04† |
OPG-endothelial activation and OPG-atherosclerosis relations were assessed in mixed regression models with adjustment for the log Framingham score and log C-reactive protein concentrations in model 1 and the log Framingham score and disease activity score in 28 joints in model 2.
↵† Significant associations.
↵* Characteristics that were non-normally distributed and were logarithmically transformed prior to entering them in linear regression models. VCAM: vascular cell adhesion molecule; ICAM: intercellular adhesion molecule.