Table 2.

Genotype and allele frequencies of 6 SNP in CARD9 and SNAPC4 in cases and controls in a Chinese Han population.

SNPGenePositionGenotype/alleleControlsCasesOR (95% CI)p
rs11145750CARD9139259249AA501 (0.508)472 (0.455)1
AG392 (0.398)446 (0.431)0.83 (0.69–1.00)
GG93 (0.094)119 (0.115)0.74 (0.55–0.99)0.044
A1394 (0.707)1390 (0.670)1
G578 (0.293)684 (0.330)0.84 (0.74–0.96)0.012
rs3812555CARD9139261933TT807 (0.743)888 (0.787)1
CT252 (0.232)224 (0.199)1.24 (1.01–1.52)
CC27 (0.025)16 (0.014)1.86 (0.99–3.47)0.023
T1866 (0.859)2000 (0.887)1
C306 (0.141)256 (0.113)1.28 (1.07–1.53)0.006
rs3812556CARD9139261991AA649 (0.591)641 (0.580)1
AG384 (0.349)395 (0.357)0.96 (0.80–1.15)
GG66 (0.060)70 (0.063)0.93 (0.65–1.33)0.861
A1682 (0.765)1677 (0.758)1
G516 (0.235)535 (0.242)0.96 (0.84–1.10)0.580
rs4077515CARD9139266496CC513 (0.563)570 (0.519)1
CT334 (0.367)439 (0.399)0.85 (0.70–1.02)
TT64 (0.070)90 (0.082)0.79 (0.56–1.11)0.128
C1360 (0.746)1579 (0.718)1
T462 (0.254)619 (0.282)0.87 (0.75–1.00)0.046
rs3812571SNAPC4139275294GG610 (0.556)540 (0.494)1
GC410 (0.373)460 (0.421)0.79 (0.66–0.94)
CC78 (0.071)93 (0.085)0.74 (0.54–1.02)0.015
G1630 (0.742)1540 (0.704)1
C566 (0.258)646 (0.296)0.83 (0.72–0.95)0.005
rs11145835SNAPC4139284452AA851 (0.776)802 (0.721)1
AG229 (0.209)280 (0.252)0.77 (0.63–0.94)
GG16 (0.015)30 (0.027)0.50 (0.27–0.93)0.005
A1931 (0.881)1884 (0.847)1
G261 (0.119)340 (0.153)0.75 (0.63–0.89)0.001
  • rs11145835 joint p = 0.0008, OR 1.43 (CI 1.24–1.65). rs3812571 joint p = 0.07, OR 1.13 (CI 1.01–1.32). SNP: single-nucleotide polymorphisms; CARD9: caspase recruitment domain-containing protein 9; SNAPC4: small nuclear RNA-activating complex polypeptide 4.