(A) Univariate linear regression models between sleep quality scores and DAS28-CRP as a continuous variable. | |||||||||
---|---|---|---|---|---|---|---|---|---|
ESS | AIS | PSQI | |||||||
Estimate | p | Model R2 | Estimate | p | Model R2 | Estimate | p | Model R2 | |
DAS28 | Relationship not statistically significant | 0.898 | < 0.0001 | 0.0769 | 0.69459 | < 0.0001 | 0.0580 |
(B) Univariate logistic regression models between sleep quality scores and DAS28-CRP as a continuous variable. | ||||||
---|---|---|---|---|---|---|
ESS | AIS | PSQI | ||||
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
DAS28 | Relationship not statistically significant | 1.300 (1.104–1.530) | 0.0016 | 1.409 (1.173–1.692) | 0.0002 |
(C) Multivariate linear regression models by sleep scale with DAS28-CRP as a continuous variable. | ||||||||
---|---|---|---|---|---|---|---|---|
ESS | Estimate | p | AIS | Estimate | p | PSQI | Estimate | p |
R2 = 0.235 | R2 = 0.437 | R2 = 0.391 | ||||||
p < 0.0001 | p < 0.0001 | p < 0.0001 | ||||||
n = 264 | n = 286 | n = 274 | ||||||
DAS28 | −0.507 | 0.0248 | DAS28 | 0.478 | 0.0034 | DAS28 | 0.336 | 0.0269 |
PANAS Score N | 0.144 | 0.0084 | Concurrent medication: glucocorticoids | 0.976 | 0.0417 | Sleep medication | 3.245 | < 0.0001 |
SF-36 General Health | 0.220 | 0.0213 | Comorbidities | 1.588 | 0.0152 | Living with partner | −1.017 | 0.0376 |
SF-36 Mental Health | 0.238 | 0.0499 | PANAS Score N | 0.224 | < 0.0001 | PANAS Score N | 0.182 | < 0.0001 |
SF-36 Vitality | −0.283 | 0.0478 | PANAS Score P | −0.096 | 0.0028 | PANAS Score P | –0.069 | 0.0250 |
(D) Multivariate logistic regression models by sleep scale with DAS28-CRP as a continuous variable. | ||||||||
---|---|---|---|---|---|---|---|---|
ESS | OR (95% CI) | p | AIS | OR (95% CI) | p | PSQI | OR (95% CI) | p |
n = 261 | n = 286 | n = 270 | ||||||
LR < 0.0001 | LR < 0.0001 | LR < 0.0001 | ||||||
Score < 0.0001 | Score < 0.0001 | Score < 0.0001 | ||||||
Wald = 0.0021 | Wald = 0.0001 | Wald = 0.0003 | ||||||
DAS28 | 2.388 (1.142–4.993) | 0.0207 | DAS28 | 1.229 (1.002–1.508) | 0.0483 | DAS28 | 1.348 (1.058–1.718) | 0.0157 |
PANAS Score N | 1.105 (1.035–1.180) | 0.0029 | Comorbidities | 2.324 (1.023–5.277) | 0.0439 | Sleep medication | 16.741 (3.607–77.700) | 0.0003 |
SF-36 General Health | 1.154 (1.025–1.298) | 0.0174 | Caffeinated drinks | 2.297 (1.017–5.183) | 0.0453 | PANAS Score N | 1.106 (1.049–1.166) | 0.0002 |
SF-36 Mental Health | 1.205 (1.034–1.403) | 0.0167 | PANAS Score N | 1.097 (1.050–1.146) | < 0.001 | |||
SF-36 Role Physical | 0.865 (0.759–0.984) | 0.0280 | PANAS Score P | 0.961 (0.924–0.999) | 0.0466 | |||
SF-36 Vitality | 0.813 (0.679–0.972) | 0.0234 |
For multivariate linear and logistic regression models, only factors found to be significantly associated with sleep quality are presented. For multivariate linear regression models: covariate estimate > 0: increase of the covariate leads to an increase of sleep quality score (worsens sleepiness); covariate estimate < 0: increase of the covariate leads to a decrease of sleep quality score (improves sleepiness). For multivariate logistic regression models: OR < 1: means that the variable reduces the risk of having poor sleep quality and denotes a negative relationship of the covariate with the risk of having excessive daytime sleepiness; OR > 1: means that the variable increases the risk of having poor sleep quality and denotes a positive relationship of the covariate with the risk of having excessive daytime sleepiness. AIS: Athens Insomnia Scale; DAS28-CRP: 28-joint Disease Activity Score (C-reactive protein); ESS: Epworth Sleepiness Scale; LR: likelihood ratio; PANAS P and N: Positive and Negative Affect Schedule positive and negative emotions; PSQI: Pittsburgh Sleep Quality Index; SF-36: Medical Outcomes Study Short Form-36 Health Survey.