Test properties for the prediction of coronary event at a particular visit, based on TC:HDL-C cutpoint up to the prior visit. Positive predictive values (PPV) relate to lipid levels greater than specified cutpoints. Negative predictive values (NPV) related to levels less than specified cutpoints. Patients (n = 42) who had only 1 lipid measurement were excluded from these analyses.
| Cutpoint | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|
| Mean TC:HDL-C up to prior visit | ||||
| 4.0 | 42.9% (21.8, 66.0) | 71.4% (66.4, 76.0) | 8.0% (3.7, 14.6) | 95.6% (92.4, 97.7) |
| 4.5 | 33.3% (14.6, 57.0) | 84.3% (80.1, 87.9) | 10.9% (4.5, 21.3) | 95.6% (92.8, 97.6) |
| 5.0 | 23.8% (8.2, 47.2) | 89.0% (85.3, 92.0) | 11.1% (3.7, 24.1) | 95.3% (92.5, 97.3) |
| TAM TC:HDL-C up to prior visit | ||||
| 4.0 | 42.9% (21.8, 66.0) | 71.6% (66.7, 76.2) | 8.0% (3.7, 14.7) | 95.6% (92.4, 97.7) |
| 4.5 | 33.3% (14.6, 57.0) | 83.8% (79.5, 87.4) | 10.6% (4.3, 20.6) | 95.6% (92.7, 97.6) |
| 5.0 | 23.8% (8.2, 47.2) | 89.0% (85.3, 92.0) | 11.1% (3.7, 24.1) | 95.3% (92.5, 97.3) |
HDL-C: high-density lioprotein cholesterol; TAM: time-adjusted mean; TC:HDL-C: total cholesterol:HDL-C ratio.