Comparison of African American (AA) and non-Hispanic white children with juvenile idiopathic arthritis-associated uveitis (JIA-U).
| AA, n = 13 | White, n = 446 | p* | |
|---|---|---|---|
| Demographic characteristics | |||
| Age at time of study, yrs, mean ± SD | 12.3 ± 4.6 | 11.1 ± 4.5 | 0.352 |
| Sex, female, n (%) | 8 (61.5) | 345 (77.4) | 0.315 |
| Disease characteristics | |||
| Age at arthritis onset, yrs ± SD | 8.0 ± 5.1 | 4.2 ± 3.5 | 0.035* |
| JIA subtype, n (%) | 0.138 | ||
| Systemic | 0 (0.0) | 2 (0.4) | 1.000 |
| Polyarticular RF-negative | 1 (7.7) | 108 (24.7) | 0.168 |
| Polyarticular RF-positive | 0 (0.0) | 3 (0.7) | 1.000 |
| Oligoarticular persistent | 5 (38.5) | 186 (42.7) | 0.815 |
| Oligoarticular extended | 2 (15.4) | 64 (14.7) | 0.917 |
| Psoriatic | 0 (0.0) | 31 (7.1) | 0.325 |
| Enthesitis-related | 4 (30.8) | 30 (6.9) | 0.001* |
| Undifferentiated | 1 (7.7) | 13 (3.0) | 0.323 |
| No. current active joints, mean ± SD | 0.9 ± 2.0 | 0.8 ± 1.6 | 0.879 |
| < 5 joints ever affected, n (%) | 5 (41.8) | 202 (45.3) | 0.803 |
| Imaging evidence of joint damage, n (%) | 5 (41.7) | 86 (23.1) | 0.135 |
| Laboratory data, n (%) | |||
| ANA-positive | 4 (44.4) | 69 (49.6) | 1.000 |
| RF-positive | 0 (0.0) | 2 (1.5) | 1.000 |
| HLA-B27–positive | 4 (40.0) | 43 (18.1) | 0.100 |
| ACPA-positive | 1 (20.0) | 3 (2.3) | 0.140 |
| QOL measuresa | |||
| Physician global assessment | 2.2 ± 1.9 | 1.2 ± 1.7 | 0.050 |
| CHAQ | 0.35 ± 0.60 | 0.26 ± 0.50 | 0.604 |
| Patient/parent pain scale score | 2.31 ± 2.18 | 2.02 ± 2.49 | 0.650 |
| Parent/subject overall well-being score | 2.38 ± 2.43 | 1.90 ± 2.10 | 0.417 |
| Health-related QOL, n (%) | |||
| Excellent | 2 (15.4) | 122 (27.8) | 0.323 |
| Very good | 8 (61.5) | 185 (42.1) | 0.164 |
| Good | 3 (23.1) | 116 (26.4) | 0.787 |
| Poor | 0 (0) | 15 (3.4) | 0.497 |
| Very poor | 0 (0) | 1 (0.2) | 1.000 |
| Parent/subject assessment of disease activity | 2.38 ± 2.40 | 2.11 ± 2.63 | 0.689 |