Table 4.

Test properties for the prediction of coronary event at a particular visit, based on LDL-C and TG cutpoint up to the prior visit. Positive predictive values (PPV) relate to lipid levels greater than specified cutpoints. Negative predictive values (NPV) related to levels less than specified cutpoints. Patients (n = 42) who had only 1 lipid measurement were excluded from these analyses.

Cutpoint (mmol/l)Sensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)
Mean LDL-C up to prior visit
2.085.7% (63.7, 97.0)12.7% (9.4, 16.5)5.4% (3.2, 8.4)93.9% (83.1, 98.7)
2.566.7% (43.0, 85.4)53.4% (48.1, 58.7)7.7% (4.2, 12.5)96.5% (93.0, 98.6)
3.257.1% (34.0, 78.2)67.2% (62.1, 72.0)9.2% (4.8, 15.5)96.4% (93.4, 98.4)
TAM LDL-C up to prior visit
2.085.7% (63.7, 97.0)12.1% (8.9, 15.9)5.3% (3.2, 8.3)93.6% (82.5, 98.7)
2.566.7% (43.0, 85.4)35.8% (30.9, 41.0)5.7% (3.1, 9.3)94.9% (89.8, 97.9)
3.257.1% (34.0, 78.2)67.5% (62.4, 72.3)9.2% (4.9, 15.6)96.5% (93.4, 98.4)
Mean TG up to prior visit
1.747.6% (25.7, 70.2)62.0% (56.8, 67.0)6.8% (3.3, 12.1)95.3% (91.8, 97.7)
2.038.1% (18.1, 61.6)73.0% (68.1, 77.5)7.5% (3.3, 14.3)95.3% (92.1, 97.5)
TAM TG up to prior visit
1.747.6% (25.7, 70.2)62.3% (57.1, 67.3)6.8% (3.3, 12.2)95.4% (91.9, 97.7)
2.038.1% (18.1, 61.6)71.9% (67.0, 76.5)7.3% (3.2, 13.8)95.3% (92.0, 97.5)
  • LDL-C: low-density lipoprotein cholesterol; TAM: time-adjusted mean; TG: triglyceride.