Table 3.

Time-dependent proportional hazards regression models for coronary events including only lipid measures and age.

Most Recent Lipid Measurement#Mean of All Lipid Measurements#Time-adjusted Mean of All Lipid Measurements#
HR* (95% CI)pHR* (95% CI)pHR* (95% CI)p
LDL-C Models
  LDL-C1.20 (0.76, 1.92)0.431.81 (1.18, 2.77)0.00651.83 (1.19, 2.81)0.006
  Age, yrs1.07 (1.03, 1.10)0.00061.06 (1.03, 1.10)0.00071.06 (1.03, 1.10)0.0007
HDL-C Models
  HDL-C1.29 (0.60, 2.78)0521.59 (0.64, 3.94)0.321.46 (0.58, 3.62)0.42
  Age, yrs1.07 (1.03, 1.11)0.00041.07 (1.03, 1.11)0.00041.07 (1.03, 1.11)0.0004
TC:HDL-C Ratio Models
  TC:HDL-C1.17 (0.81, 1.68)0.411.42 (1.01, 2.00)0.041.43 (1.02, 2.00)0.04
  Age, yrs1.06 (1.03, 1.10)0.00071.06 (1.02, 1.10)0.0011.06 (1.02, 1.10)0.001
TG Models
  TG1.94 (1.26, 2.99)0.0032.21 (1.39, 3.54)0.00092.11 (1.32, 3.39)0.0019
  Age, yrs1.06 (1.02, 1.10)0.00081.06 (1.02, 1.10)0.00131.06 (1.02, 1.10)0.0013
  • # The “most recent lipid measurement model” included the 42 patients with only 1 lipid measurement, whereas the other 2 models did not include these patients.

  • * HR: hazard ratio for each 1 year increase in age, or 1 mmol/l increase in LDL-C, HDL-C, or TG, or 1 unit increase in TC:HDL-C ratio. LDL-C: low-density lipoprotein cholesterol (mmol/l); HDL-C: high-density lipoprotein cholesterol (mmol/l); TC:HDL-C: total cholesterol:HDL-C ratio; TG: triglycerides.