Table 5.

Fracture risk [hazard ratio (HR)] for any first fragility fracture or first major osteoporotic fracture (fragility fracture at proximal femur, thoracic/lumbar vertebrae, distal radius, or proximal humerus) among women and men with RA from Olmsted County, Minnesota; stratified by age at diagnosis and relative to their matched non-RA pair.

Sex and Age GroupsSubjectsTotal nFragility FracturesMajor Osteoporotic Fractures
nPer 1000 P-YHR (95% CI)nPer 1000 P-YHR (95% CI)
All WomenRA82228230.81.63 (1.36–1.96)21223.21.78 (1.43–2.21)
Non-RA82219321.112914.1
Age ≥ 50RA51420140.01.43 (1.16–1.77)15831.51.46 (1.15–1.86)
Non-RA51415130.111322.5
Age < 50RA3088119.62.34 (1.61–3.42)5413.14.05 (2.31–7.10)
Non-RA3084210.2163.9
Age < 50*RA3083216.31.95 (1.08–3.51)147.14.80 (1.38–16.73)
Non-RA308178.731.5
All MenRA3498824.21.40 (1.02–1.93)6818.71.65 (1.13–2.42)
Non-RA3496517.94311.8
Age ≥ 50RA2396330.91.34 (0.92–1.94)5125.01.77 (1.13–2.77)
Non-RA2395024.53115.2
Age < 50RA1102515.71.74 (0.91–3.30)1710.71.49 (0.71–3.12)
Non-RA110159.4127.5
Age < 50*RA11068.10.82 (0.28–2.45)34.00.75 (0.17–3.35)
Non-RA11079.445.4
  • * Followup ended at age ≤ 50 yrs. Note that the number of fractures observed may differ from those reported in Table 2 or 3 because only the first fracture of each type per subject was counted. P-Y: person years.