Mean change from baseline in WOMAC pain subscale, physical function, and joint stiffness scores (ITT population).
| WOMAC Subscale Score | Mean Change from Baseline (SD) | |||
|---|---|---|---|---|
| Week 2 | Week 6 | Week 9 | Week 12 | |
| Pain | ||||
| IDEA-033 | −1.21 (1.61) | −1.76 (1.88) | −1.85 (1.92) | −1.98 (1.97) |
| TDT 064 | −1.46 (1.79) | −2.08 (1.94) | −2.20 (1.98) | −2.33 (2.12) |
| MW = 0.4683 | MW = 0.4559 | MW = 0.4521 | MW = 0.4505 | |
| p = 0.098 | p = 0.036 | p = 0.025 | p = 0.022 | |
| Physical function | ||||
| IDEA-033 | −1.28 (1.66) | −1.80 (1.95) | −1.93 (2.01) | −2.02 (2.07) |
| TDT 064 | −1.51 (1.88) | −2.07 (2.01) | −2.18 (2.10) | −2.32 (2.23) |
| MW = 0.4687 | MW = 0.4605 | MW = 0.4633 | MW = 0.4570 | |
| p = 0.101 | p = 0.054 | p = 0.068 | p = 0.040 | |
| Joint stiffness | ||||
| IDEA-033 | −1.38 (1.84) | −1.96 (2.12) | −2.09 (2.19) | −2.23 (2.22) |
| TDT 064 | −1.62 (2.08) | −2.21 (2.11) | −2.28 (2.17) | −2.48 (2.28) |
| MW = 0.4648 | MW = 0.4608 | MW = 0.4713 | MW = 0.4655 | |
| p = 0.076 | p = 0.055 | p = 0.121 | p = 0.080 | |
WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index; ITT: intent-to-treat; MW: Mann-Whitney estimators for IDEA-033 versus TDT 064; p values in favor of TDT 064 calculated using Wilcoxon-Mann-Whitney U test based on 1-sided 97.5% CI.