Anti-PAD4 associations in probands.
| Characteristic | Anti-PAD4+, n = 24 | Anti-PAD4–, n = 58 | p |
|---|---|---|---|
| Disease duration, yrs, median | 19.3 | 9.8 | 0.0082 |
| Sex, n (%) female | 22 (91.7) | 49 (84.5) | 0.495 |
| Ever-smoker, n (%) | 13 (54.2) | 44 (75.9) | 0.067 |
| Current smoker, n (%) | 5/22 (22.7) | 26/57 (45.6) | 0.157 |
| CCP2-positive, (≥ 40 AU), n (%) | 24 (100) | 44/57 (77.2) | 0.008 |
| Rheumatoid factor-positive (≥ 50 IU), n (%) | 22/23 (95.7) | 42/51 (82.4) | 0.158 |
| Any shared-epitope allele, n (%) | 20/21 (95.2) | 40/44 (90.9) | 1.000 |