The 1912 report of Hakaru Hashimoto (1881–1934) and mid-20th century articles on this disease*.
| Author | Findings in Hashimoto’s Disease (HD) and Interpretations |
|---|---|
| Hashimoto, 19122 | Lymphomatous firm diffuse goiters were found incidentally in 4 middle-aged women, their cause stated as . . . “probable that a chronic inflammatory process may have occurred” . . . |
| McConahey, 19543 | Thyroid extract therapy diminished the size of goiters in HD, but not adenomatous goiters. |
| Sommers and Meissner, 19544 | Basement membrane changes found in thyroid follicle epithelium were proposed to be the primary lesions in HD. |
| Skillern, 19565 | HD proposed to be a primary thyroid failure with compensatory thyroid enlargement. |
| Roitt, 19566 | Antithyroid precipitating antibodies were found in 6 patients with HD, but in none of 13 other thyroid disease patients, initiating the autoimmune theory of causation. |
| Doniach and Roitt, 19577 | Precipitating antibodies to purified thyroglobulin were found in sera of 25 of 30 HD patients, but in none of 105 thyrotoxic or 103 nontoxic nodular goiter patients. |
| Smart and Owen, 19618 | Confirmed that thyroid replacement therapy of HD patients for more than a year was associated with significantly lower serum antithyroid antibody titers. |
| Stuart and Allan, 19589 | Demonstrated a correlation between the extent of basement membrane damage and antithyroid antibody titers. |
| Becker, 196310 | A large patient sample report on the connective tissue disease and symptoms associated with Hashimoto’s thyroiditis. |
↵* Prominent reports on HD, before the author’s doctoral studies and publications on this topic.