Baseline characteristics of patients with spondyloarthritis (SpA) who have received, or not received, anti-tumor necrosis factor (TNF) during the followup period of the study.
| Characteristics | Anti-TNF Therapy Group (n = 59) | Ankylosing Spondylitis Control Group (n = 34) | p |
|---|---|---|---|
| Age, years, mean (SD) | 40.3 (11.0) | 39.5 (12.1) | 0.802 |
| Sex, M/F (% male) | 50/9 (84.8) | 21/13 (61.8) | 0.021 |
| Disease duration, years, mean (SD) | 13.3 (10.5) | 9.7 (6.1) | 0.024 |
| HLA-B27, n (%) | 50 (87.7) | 30 (88.2) | 1 |
| Inflammatory bowel disease, n (%) | 9 (15.3) | 1 (2.9) | 0.087 |
| Psoriasis, n (%) | 11 (18.6) | 8 (24.2) | 0.595 |
| History of uveitis, n (%) | 23 (39.0) | 15 (44.1) | 0.666 |
| Current intake of steroids, n (%) | 7 (11.9) | 0 (0) | — |
| Current use of DMARD, n (%) | 17 (28.8) | 6 (17.7) | 0.229 |
| BASDAI, mean (SD) | 52.3 (16.4) | 27.9 (18.7) | < 0.0001 |
| BASFI, mean (SD) | 42.7 (21.9) | 16.1 (18.7) | < 0.0001 |
| CRP, mg/l, mean (SD) | 25.2 (22.0) | 14.2 (25.7) | < 0.0001 |
| ESR, mm/h, mean (SD) | 28.4 (20.4) | 9.9 (10.3) | < 0.0001 |
| Height, cm, mean (SD) | 171.1 (7.8) | 168.5 (7.8) | 0.263 |
| Weight, kg, mean (SD) | 73.3 (14.0) | 66.9 (11.8) | 0.032 |
| BMI, kg/m2, mean (SD) | 25.0 (4.2) | 23.5 (3.7) | 0.113 |
| Smoking, n (%) | 22 (37.3) | 10 (33.3) | 0.817 |
| Alcohol intake, ≥ 2 U/day, n (%) | 5 (8.5) | 0 (0) | 0.163 |
| Radiographic sacroiliitis, n (%) | 57 (96.6) | 34 (100) | 0.81 |
| Lumbar spine T-score, mean (SD) | −1.1 (1.6) | −1.0 (1.4) | 0.451 |
| Lumbar spine BMD, g/cm2, mean (SD) | 0.99 (0.18) | 1.01 (0.15) | 0.396 |
| Total hip T-score, mean (SD) | −1.1 (1.0) | −0.8 (0.8) | 0.14 |
| Total hip BMD, g/cm2, mean (SD) | 0.91 (0.13) | 0.94 (0.11) | 0.275 |
| Femoral neck T score, mean (SD) | −1.7 (1.1) | −1.1 (1.0) | 0.026 |
| Femoral neck BMD, g/cm2, mean (SD) | 0.78 (0.11) | 0.82 (0.11) | 0.071 |
| Osteoporosis, T ≤ −25, n, % | 15 (31) | 8 (24) | 0.597 |
| Total lean mass, kg, mean (SD) | 50.5 (10.5) | 49.3 (9.8) | 0.515 |
| Total fat mass, kg, mean (SD) | 19.2 (8.2) | 15.5 (7.3) | 0.050 |
DMARD: disease-modifying antirheumatic drugs; BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; BASFI: Bath Ankylosing Spondylitis Functional Index; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; BMI: body mass index; BMD: bone mineral density.