Baseline characteristics of the 98 study patients with nontuberculous mycobacteria lung disease classified by radiographic features. Data are no. (%) or ± SD.
| Radiographic Features | |||||
|---|---|---|---|---|---|
| Characteristic | NB | FC | FC+NB | Others* | p† |
| No. patients | 56 (100) | 14 (100) | 16 (100) | 12 (100) | |
| Female | 48 (85.7) | 2 (14.3) | 9 (56.3) | 6 (50.0) | < 0.001 |
| Age, mean yrs ± SD | 66.6 ± 11.0 | 71.4 ± 6.9 | 67.8 ± 9.0 | 68.2 ± 8.4 | 0.248 |
| Smoker | 10 (17.9) | 11 (78.6) | 7 (43.8) | 4 (33.3) | < 0.001 |
| Comorbidity | 34 (60.7) | 14 (100.0) | 14 (87.5) | 12 (100.0) | 0.002 |
| Respiratory disease | 15 (26.8) | 13 (92.9) | 10 (62.5) | 11 (91.7) | < 0.001 |
| UIP | 1 (1.8) | 0 (0.0) | 5 (31.3) | 10 (83.3) | 0.002 |
| Pulmonary emphysema | 1 (1.8) | 8 (57.1) | 0 (0.0) | 0 (0.0) | < 0.001 |
| Previous pulmonary tuberculosis | 5 (8.9) | 0 (0.0) | 2 (12.5) | 0 (0.0) | 0.530 |
| Bronchiolitis | 6 (10.7) | 1 (7.1) | 0 (0.0) | 0 (0.0) | 0.444 |
| Others | 2 (3.6) | 4 (28.6) | 3 (18.8) | 1 (8.3) | 0.08 |
| Systemic disease | 23 (41.1) | 9 (64.3) | 8 (50.0) | 7 (58.3) | 0.244 |
| Antirheumatic drugs | 0.009 | ||||
| MTX | 23 (41.1) | 3 (21.4) | 2 (12.5) | 3 (25.0) | |
| Corticosteroid | 8 (14.3) | 6 (42.9) | 8 (50.0) | 5 (41.7) | |
| TNF antagonists/tocilizumab | 5 (8.9) | 0 (0.0) | 1 (6.3) | 0 (0.0) | |
| Others | 20 (35.7) | 5 (35.7) | 5 (31.3) | 4 (33.3) | |
| Body mass index, kg/m2 | 20.1 ± 2.7 | 18.2 ± 2.3 | 17.8 ± 3.0 | 20.8 ± 3.5 | 0.011 |
| Hemoglobin, g/dl | 12.2 ± 1.5 | 12.2 ± 1.4 | 12.2 ± 1.7 | 12.5 ± 1.5 | 0.972 |
| Albumin, g/dl | 3.7 ± 0.6 | 3.2 ± 0.4 | 3.4 ± 0.5 | 3.7 ± 0.4 | 0.011 |
| ESR, mm/h | 55.5 ± 32.2 | 77.9 ± 40.9 | 80.8 ± 39.2 | 67.7 ± 30.4 | 0.041 |
| CRP, mg/dl | 2.41 ± 3.71 | 6.66 ± 8.07 | 10.48 ± 10.68 | 3.71 ± 7.08 | 0.001 |
| Nontuberculous mycobacteria species | 0.143 | ||||
| MAC | 49 (87.5) | 11 (78.6) | 15 (93.8) | 7 (58.3) | |
| M. kansasii | 1 (1.8) | 2 (14.3) | 1 (6.3) | 2 (16.7) | |
| M. gordonae | 5 (8.9) | 0 (0.0) | 0 (0.0) | 1 (8.3) | |
| Others | 1 (1.8) | 1 (7.1) | 0 (0.0) | 2 (16.7) | |
| Initial management | < 0.001 | ||||
| Observation or 1 drug | 51 (91.1) | 10 (71.4) | 8 (50.0) | 7 (58.3) | |
| ≥ 2 drugs | 5 (8.9) | 4 (28.6) | 8 (50.0) | 5 (41.7) | |
↵* Others includes several nodules with consolidation (n = 2) and unclassifiable (n = 10) cases.
↵† In relation to all types of radiographic features except Others. NB: nodular/bronchiectatic; FC: fibrocavitary; UIP: usual interstitial pneumonia; MTX: methotrexate; TNF: tumor necrosis factor; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; MAC: Mycobacterium avium complex.