Table 2.

Comparisons of the 3′UTR HLA-G allele and genotype frequencies between patients with systemic lupus erythematosus (SLE) and healthy blood donors from 2 Brazilian populations: southeastern (SE) from Ribeirão Preto and northeastern (NE) from Recife.

	SE Brazil^*					NE Brazil^*					Total^**
Variables	Case %	Cont. %	OR	95% CI	p	Case %	Cont. %	OR	95% CI	p	Case %	Cont. %	OR	95% CI	p^a	p_c
Alleles
’14bp INDEL
14-bp DEL	52.50	59.18	1.00			55.00	62.20	1.00			53.16	60.58	1.00
14-bp INS	47.50	40.82	1.30	0.81–2.10	0.283	45.00	37.80	2.02	0.94–4.48	0.075	46.84	39.42	1.49	1.00–2.23	0.053	0.424
’+3003 C/T
’+3003 C	8.57	13.27	1.00			12.00	6.69	1.00			9.47	10.22	1.00
’+3003 T	91.43	86.73	1.68	0.80–3.45	0.165	88.00	93.31	0.35	0.10–1.19	0.096	90.53	89.78	1.13	0.60–2.10	0.705
’+3010 C/G
’+3010 C	61.79	52.40	1.00			68.00	54.33	1.00			63.42	53.30	1.00
’+3010 G	38.21	47.60	0.71	0.44–1.14	0.151	32.00	45.67	0.40	0.18–0.86	0.021	36.58	46.70	0.59	0.39–0.87	0.008	0.064
’+3027 A/C
’+3027 A	3.57	5.78	1.00			6.00	3.54	1.00			4.21	4.74	1.00
’+3027 C	96.43	94.22	2.27	0.75–6.48	0.131	94.00	96.46	0.17	0.03–1.09	0.054	95.79	95.26	1.25	0.46–3.19	0.654
’+3035 C/T
’+3035 C	83.57	85.37	1.00			80.00	87.01	1.00			82.63	86.13	1.00
’+3035 T	16.43	14.63	1.15	0.60–2.25	0.681	20.00	12.99	4.33	1.47–3.85	0.010	17.37	13.87	1.66	0.95–2.95	0.080
’+3142 C/G
’+3142 C	38.21	46.60	1.00			31.00	44.88	1.00			36.32	45.80	1.00
’+3142 G	61.79	53.40	1.41	0.88–2.28	0.153	69.00	55.12	2.74	1.26–6.13	0.012	63.68	54.20	1.74	1.17–2.61	0.006	0.048
’+3187 A/G
’+3187 A	75.36	74.15	1.00			86.96	70.08	1.00			78.23	72.26	1.00
’+3187 G	24.64	25.85	0.86	0.51–1.48	0.585	13.04	29.92	0.15	0.05–0.40	0.000	21.77	27.74	0.57	0.36–0.89	0.013	0.104
’+3196 C/G
’+3196 C	68.21	74.14	1.00			76.09	76.38	1.00			70.16	75.18	1.00
’+3196 G	31.79	25.86	1.28	0.76–2.20	0.352	23.91	23.62	0.91	0.37–2.21	0.833	29.84	24.82	1.20	0.77–1.88	0.428
Genotypes^***
’14-bp DEL/14-bp DEL	30.71	38.78	0.71	0.36–1.45	0.344	38.00	40.16	0.63	0.21–1.85	0.403	32.63	39.42	0.67	0.38–1.19	0.169
’14-bp DEL/14-bp INS	43.57	40.82	1.14	0.58–2.27	0.697	34.00	44.09	0.62	0.20–1.85	0.391	41.05	42.34	0.98	0.56–1.78	0.942
’14-bp INS/14-bp INS	25.71	20.41	1.32	0.60–3.03	0.503	28.00	15.75	1.32	0.60–3.03	0.503	26.32	18.25	1.82	0.92–3.70	0.094
’+3003 C/+3003 C						2.00	0.00			0.992	0.53	0.00			0.987
’+3003 C/+3003 T	17.14	26.53	0.55	0.25–1.22	0.138	20.00	13.39	2.94	0.71–12.5	0.140	17.89	20.44	0.80	0.40–1.59	0.516
’+3003 T/+3003 T	82.86	73.47	1.82	0.82–4.00	0.138	78.00	86.61	0.31	0.07–1.22	0.100	81.58	79.56	1.19	0.60–2.33	0.605
’+3010 C/+3010 C	36.43	28.77	1.67	0.81–3.57	0.177	46.00	29.13	2.44	0.81–8.33	0.116	38.95	28.94	1.96	1.06–3.70	0.033	0.792
’+3010 C/+3010 G	50.71	47.26	0.83	0.42–1.61	0.590	44.00	50.39	1.12	0.39–3.33	0.834	48.95	48.72	0.90	0.52–1.56	0.717
’+3010 G/+3010 G	12.86	23.97	0.64	0.27–1.56	0.316	10.00	20.47	0.20	0.04–0.83	0.032	12.11	22.34	0.44	0.21–0.92	0.027	0.648
’+3027 A/+3027 A	0.00	0.68			0.986	0.00	0.79			0.994	0.00	0.73			0.983
’+3027 A/+3027 C	7.14	10.20	0.68	0.21–2.38	0.532	12.00	5.51	8.33	1.08–100.0	0.044	8.42	8.03	1.28	0.45–3.85	0.647
’+3027 C/+3027 C	92.86	89.12	1.00	0.35–2.70	0.998	88.00	93.70	0.13	0.02–0.98	0.049	91.58	91.24	1.01	0.35–2.70	0.992
’+3035 C/+3035 C	68.57	72.79	0.78	0.36–1.61	0.497	66.00	76.38	0.78	0.36–0.63	0.493	67.89	74.45	0.53	0.27–1.00	0.055
’+3035 C/+3035 T	30.00	25.17	1.43	0.62–3.13	0.362	28.00	21.26	4.55	1.16–25.0	0.042	29.47	23.36	1.92	1.00–3.85	0.055
’+3035 T/+3035 T	1.43	2.04	0.37	5.26–9.18	0.414	6.00	2.36	5.88	0.36–100.0	0.255	2.63	2.19	1.16	0.20–8.33	0.873
’+3142 C/+3142 C	13.57	21.77	0.68	0.29–1.69	0.395	10.00	20.47	0.20	0.04–0.83	0.032	12.63	21.17	0.46	0.22–0.94	0.034	0.816
’+3142 C/+3142 G	49.29	49.66	0.78	0.39–1.52	0.454	42.00	48.82	0.95	0.33–2.78	0.927	47.37	49.27	0.83	0.48–1.45	0.525
’+3142 G/+3142 G	37.14	28.57	1.72	0.84–3.70	0.147	48.00	30.71	2.86	0.95–9.09	0.066	40.00	29.56	2.04	1.14–3.85	0.021	0.504
’+3187 A/+3187 A	58.57	53.06	1.22	0.63–2.38	0.559	76.09	49.61	5.88	1.82–25.0	0.005	62.90	51.46	1.85	1.05–3.23	0.035	0.840
’+3187 A/+3187 G	33.57	42.18	0.83	0.42–1.67	0.611	21.74	40.94	0.46	0.13–1.52	0.206	30.65	41.61	0.70	0.39–1.25	0.230
’+3187 G/+3187 G	7.86	4.76	0.89	0.27–3.57	0.857	2.17	9.45	0.03	0.00–0.29	0.008	6.45	6.93	0.43	0.16–1.14	0.080
’+3196 C/+3196 C	46.43	55.17	0.68	0.34–1.32	0.253	63.04	60.63	1.35	0.45–4.17	0.585	50.54	57.72	0.80	0.45–1.41	0.442
’+3196 C/+3196 G	43.57	37.93	1.47	0.74–2.94	0.281	26.09	31.50	1.47	0.74–2.94	0.281	39.25	34.93	1.16	0.65–2.08	0.607
’+3196 G/+3196 G	10.00	6.90	1.10	0.35–4.00	0.883	10.87	7.87	1.67	0.24–1.25	0.613	10.22	7.35	1.28	0.48–3.70	0.632

↵a Some comparisons did not remain statistically significant at the 0.05 significance level for the alleles (alpha_c = 0.0063) and genotype (alpha_c = 0.0021) distribution, after the Bonferroni correction.
↵* Adjusted by sex, skin color, and age.
↵** Adjusted by sex, skin color, age, and place of origin.
↵*** Genotype frequencies were calculated by comparing each genotype against the others.