Nontuberculous Mycobacteria Species | ||||||
---|---|---|---|---|---|---|
Characteristics | Total | MAC | M. kansasii | M. gordonae | Others* | p† |
No. patients | 98 (100) | 82 (100) | 6 (100) | 6 (100) | 4 (100) | |
Female | 65 (66.3) | 58 (70.7) | 2 (33.3) | 4 (66.7) | 1 (25.0) | 0.204 |
Age, mean yrs ± SD | 67.6 ± 9.9 | 67.8 ± 10.3 | 64.2 ± 8.3 | 66.5 ± 7.2 | 72.0 ± 6.2 | 0.667 |
Smoker | 32 (32.7) | 24 (29.3) | 4 (66.7) | 3 (50.0) | 1 (25.0) | 0.083 |
Comorbidity | 74 (75.5) | 59 (72.0) | 6 (100.0) | 5 (83.3) | 4 (100.0) | 0.554 |
Respiratory disease | 49 (50.0) | 37 (45.1) | 5 (83.3) | 4 (66.7) | 3 (75.0) | 0.117 |
UIP | 16 (16.3) | 10 (12.2) | 3 (50.0) | 1 (16.7) | 2 (50.0) | 0.049 |
Pulmonary emphysema | 9 (9.2) | 8 (9.8) | 0 (0.0) | 0 (0.0) | 1 (25.0) | 1.000 |
Previous pulmonary tuberculosis | 7 (7.1) | 6 (7.3) | 0 (0.0) | 1 (16.7) | 0 (0.0) | 0.629 |
Bronchiolitis | 7 (7.1) | 5 (6.1) | 1 (16.7) | 1 (16.7) | 0 (0.0) | 0.218 |
Others | 10 (10.2) | 8 (9.8) | 1 (16.7) | 1 (16.7) | 0 (0.0) | 0.374 |
Systemic disease | 47 (48.0) | 39 (47.6) | 3 (50.0) | 3 (50.0) | 2 (50.0) | 1.000 |
Antirheumatic drugs | 0.317 | |||||
MTX | 31 (31.6) | 23 (28.0) | 2 (33.3) | 3 (50.0) | 3 (75.0) | |
Corticosteroid | 27 (27.6) | 22 (26.8) | 3 (50.0) | 1 (16.7) | 1 (25.0) | |
TNF antagonists/tocilizumab | 6 (6.1) | 4 (4.9) | 0 (0.0) | 2 (33.3) | 0 (0.0) | |
Others | 34 (34.7) | 33 (40.2) | 1 (16.7) | 0 (0.0) | 0 (0.0) | |
Body mass index, kg/m2 | 19.6 ± 3.0 | 19.4 ± 2.8 | 18.4 ± 3.5 | 23.5 ± 3.7 | 19.8 ± 1.4 | 0.044 |
Hemoglobin, g/dl | 12.2 ± 1.5 | 12.2 ± 1.4 | 12.0 ± 2.5 | 12.7 ± 1.4 | 13.0 ± 0.6 | 0.584 |
Albumin, g/dl | 3.6 ± 0.6 | 3.6 ± 0.5 | 3.2 ± 0.7 | 3.3 ± 0.6 | 3.7 ± 0.5 | 0.117 |
ESR, mm/h | 64.3 ± 35.5 | 61.7 ± 35.5 | 92.7 ± 31.8 | 67.0 ± 20.8 | 68.0 ± 47.3 | 0.160 |
CRP, mg/dl | 4.50 ± 7.00 | 4.23 ± 6.12 | 8.67 ± 14.59 | 2.51 ± 4.11 | 6.73 ± 11.79 | 0.537 |
Radiographic features | 0.143 | |||||
NB | 56 (57.1) | 49 (59.8) | 1 (16.7) | 5 (83.3) | 1 (25.0) | |
FC | 14 (14.3) | 11 (13.4) | 2 (33.3) | 0 (0.0) | 1 (25.0) | |
FC+NB | 16 (16.3) | 15 (18.3) | 1 (16.7) | 0 (0.0) | 0 (0.0) | |
Others | 12 (12.2) | 7 (8.5) | 2 (33.3) | 1 (16.7) | 2 (50.0) | |
Initial management | 0.208 | |||||
Observation or 1 drug | 76 (77.6) | 66 (80.5) | 3 (50.0) | 5 (83.3) | 2 (50.0) | |
≥ 2 drugs | 22 (22.4) | 16 (19.5) | 3 (50.0) | 1 (16.7) | 2 (50.0) |
↵* Includes M. abscessus (n = 2), M. szulgai (n = 1), and M. chelonae (n = 1).
↵† In relation to all types of nontuberculous mycobacteria species except Others. MAC: Mycobacterium avium complex; UIP: usual interstitial pneumonia; MTX: methotrexate; TNF: tumor necrosis factor; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; NB: nodular/bronchiectatic disease; FC: fibrocavitary disease.