Median of percentages of peripheral lymphocyte subsets in 24 patients with juvenile dermatomyositis seen at Visit 1 and Visit 2.
| Peripheral Lymphocyte Subsets | Visit 1, median (min, max) | Visit 2, median (min, max) | p* |
|---|---|---|---|
| T cells (CD3+) | 61.5 (32.4, 88.5) | 62.9 (26.6, 82.4) | 0.82 |
| T helper cells (CD3+CD4+) | 39.4 (20.7, 62.8) | 41.6 (15.6, 62.7) | 0.94 |
| Cytotoxic T cells (CD3+CD8+) | 13.6 (1.1, 41.8) | 16.7 (5.5, 42.7) | 0.56 |
| Activated T cells (CD3+CD69+) | 0.6 (0.0, 2.2) | 0.8 (0.0, 3.3) | 0.49 |
| B cells (CD3−CD20+) | 8.1 (0.4, 43.2) | 11.0 (0.6, 33.2) | 0.56 |
| Monocytes (CD3−CD69+) | 0.7 (0.1, 6.0) | 0.5 (0.1, 2.4) | 0.12 |
| pDC (CD123+) | 12.5 (0.0, 38.6) | 15.2 (2.5, 65.2) | 0.17 |
| NK cells (CD16+CD56+) | 2.5 (0.0, 25.6) | 7.0 (0.0, 24.8) | 0.033 |
| NK cells (CD16−CD56+) | 9.6 (0.3, 35.9) | 17.0 (2.3, 29.4) | 0.14 |
| NK cells (CD16+CD56−) | 3.9 (0.0, 22.6) | 4.2 (0.6, 32.8) | 0.98 |
| CD56+ | 16.0 (1.4, 55.5) | 23.6 (2.9, 44.0) | 0.026 |
| CD11c+ | 1.5 (0.0, 16.4) | 4.4 (0.0, 9.5) | 0.96 |
| CD123+ HLA-DR− | 10.9 (0.0, 38.5) | 13.4 (2.3, 65.2) | 0.10 |
| CD123− HLA-DR+ | 0.5 (0.0, 17.0) | 0.7 (0.0, 10.0) | 0.55 |
| CD123+ HLA-DR+ | 0.5 (0.0, 7.6) | 0.4 (0.0, 10.0) | 0.66 |
| CD3+CD20− | 62.0 (32.4, 88.5) | 65.5 (26.6, 82.3) | 0.82 |
| CD3+CD20+ | 0.2 (0.0, 1.4) | 0.2 (0.0, 0.5) | 0.44 |
| CD3+CD4− | 15.2 (3.3, 45.0) | 19.8 (10.1, 45.8) | 0.53 |
| CD3−CD4+ | 1.5 (0.1, 24.6) | 2.3 (0.0, 13.4) | 0.20 |
| CD3−CD8+ | 2.2 (0, 9.4) | 2.7 (0, 8.6) | 0.84 |
| CD3+CD8− | 40.9 (15.3, 65) | 45.4 (18.2, 63.5) | 0.79 |
| CD3+CD69− | 64.6 (30, 88.7) | 62.6 (23.5, 85.1) | 0.70 |
| HLA-DR+ CD11c− | 16.2 (0, 75.5) | 17.3 (5.3, 56.9) | 0.89 |
| HLA-DR+ CD11c+ | 0.7 (0, 16) | 1.1 (0, 6.5) | 0.45 |
| HLA-DR− CD11c+ | 0.8 (0, 14.6) | 2.7 (0.0, 9.5) | 0.46 |
↵* P values obtained from paired t-tests. NK: natural killer; pDC: plasmacytoid dendritic cells.