Table 4.

Comparisons of the frequencies of the HLA-G 3′ UTR consensus sequences associated with susceptibility to (14-bpIns/+3010C/+3142G/+3187A) or protection against SLE development (14-bpDEL/+3010G/+3142C/+3187G/A) at single (heterozygous) or double (homozygous) dose consensus sequences.

HaplotypesPatients, n = 188Controls n = 281pOR (95% CI)4
Homozygous for protection123580.0180.54 (0.32–0.91)
Other UTR165223
Homozygous for susceptibility250500.0291.67 (1.07–2.61)
Other UTR138231
Heterozygous for protection355930.4180.84 (0.56–1.25)
Other UTR133188

  • ↵1 Combination of UTR-1, -4, -6, -14 haplotypes.

  • ↵2 Combination of UTR-2, -5, -7, -15, -16 haplotypes.

  • ↵3 Combination of UTR-1, -4, -6, -14 with UTR2, -5, -7, -15, -16 haplotypes.

  • ↵4 Fisher’s 2-tailed test. SLE: systemic lupus erythematosus; UTR: untranslated region.