Expression quantitative trait locus (eQTL) analysis results between 11 single-nucleotide polymorphisms (SNP) and the “identified” 9 genes.
| SNP ID | Chr | Loc. | Allele | Role | Assn p | Gene 1 | Gene 2 | Implicated Gene | PMID for Assn | eQTL Gene | Effect | Score | Tgt. | PMID for eQTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs1600249 | 8 | 11359638 | A/C | Intron | 5.00E-06 | BLK | BLK | BLK | 21452313 | BLK | eQTL | 31.6 | LCL | Database# |
| rs2736340 | 8 | 11343973 | C/T | Interg. | 6.00E-09 | FAM167A | BLK | C8orf13 | 19503088 | BLK | eQTL | 14.5 | Mono | 20502693 |
| FAM167A | trans-QTL | 6.5 | LCL | 20220756 | ||||||||||
| FAM167A | exon-QTL | 6.4 | LCL | 20220756 | ||||||||||
| BLK | eQTL | 59.5 | LCL | Database | ||||||||||
| rs3093023 | 6 | 167534290 | A/G | Intron | 2.00E-11 | CCR6 | CCR6 | CCR6 | 20453842 | CCR6 | eQTL | 48.3 | Mono | 20502693 |
| rs3093024 | 6 | 167532793 | A/G | Intron | 8.00E-19 | CCR6 | CCR6 | CCR6 | 20453841 | CCR6 | eQTL | 50.9 | Mono | 20502693 |
| rs4810485 | 20 | 44747947 | G/T | Intron | 3.00E-09 | CD40 | CD40 | CD40 | 20453842 | CD40 | eQTL | 34.4 | Mono | 20502693 |
| rs615672 | 6 | 32574171 | C/G | Interg. | 8.00E-27 | HLA-DRB1 | HLQ-DQA1 | BTNL2 | 17554300 | HLA-DQA1 | eQTL | 102.9 | Mono | 20502693 |
| rs660895 | 6 | 32577380 | A/G | Interg. | 1.00E-108 | HLA-DRB1 | HLA-DQA1 | BTNL2 | 17804836 | HLA-DQA1 | eQTL | 10.2 | LCL | 18846210 |
| rs9272219 | 6 | 32602269 | G/T | Interg. | 1.00E-45 | HLA-DRB1 | HLA-DQA1 | BTNL2 | 21653640 | HLA-DQA1 | eQTL | 191.2 | Mono | 20502693 |
| HLA-DQB1 | eQTL | 83.2 | Mono | 20502693 | ||||||||||
| HLA-DQA1 | eQTL | 6.9 | LCL | 18846210 | ||||||||||
| HLA-DQA1 | sQTL | 13.3 | LCL | 20220758 | ||||||||||
| HLA-DRB1 | eQTL | 72.6 | Mono | 20502693 | ||||||||||
| rs3816587 | 4 | 25417244 | C/T | Intron | 9.00E-06 | ANAPC4 | ANAPC4 | P14K2B | 17554300 | ANAPC4 | eQTL | 25.3 | Mono | 20502693 |
| rs3890745 | 1 | 2553624 | A/G | Intron | 1.00E-07 | MMEL1 | MMEL1 | TNFRSF14 | 18794853 | MELL1 | eQTL | 52.8 | Mono | 20502693 |
| rs9268853 | 6 | 32429643 | C/T | Interg. | 5.00E-109 | HLA-DRB9 | HLA-DRB5 | BTNL2 | 21653640 | HLA-DRB5 | eQTL | 8.0 | LCL | 17873874 |
All eQTL have cis-effects. Database#: http://eqtl.uchicago.edu/cgi-bin/gbrowse/eqtl. “Gene 1” and “Gene 2” are the nearby genes physically located at 2 sides of SNP. “Score”:–log10 (P); LCL: lymphoblastoid cell lines; trans-QTL: transcript expression levels against SNP; exon-QTL: quantified reads for known exons by RNA sequencing against SNPs; sQTL: splicing QTL; PMID for Association: Pubmed ID for association results; PMID for eQTL: PubMed ID for eQTL results; Loc.: location; Assn: association; Tgt.: target; interg.: intergenic; trans: transcript; mono: monocytes.