HLA-G 3′ untranslated region (UTR) haplotype frequencies observed for systemic lupus erythematosus (SLE) patients and healthy controls from the 2 Brazilian populations: southeastern (SE) from Ribeirão Preto and northeastern (NE) from Recife.
| SE Brazil* | NE Brazil* | Total** | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotypes | Pt. % | Cont. % | Or | 95% CI | p | Pt. % | Cont. % | OR | 95% CI | p | Pt. % | Cont. % | OR | 95% CI | p |
| UTR1 (DTGCCCGC) | |||||||||||||||
| Others | 76.79 | 74.15 | 1.00 | 88.00 | 70.87 | 1.00 | 79.74 | 72.63 | 1.00 | ||||||
| UTR 1 | 23.21 | 25.85 | 0.81 | 0.48–1.40 | 0.451 | 12.00 | 29.13 | 0.13 | 0.05–0.36 | 0.000a | 20.26 | 27.37 | 0.52 | 0.33–0.82 | 0.005b |
| UTR2 (ITCCCGAG) | |||||||||||||||
| Others | 69.29 | 74.83 | 1.00 | 74.00 | 77.17 | 1.00 | 70.53 | 75.91 | 1.00 | ||||||
| UTR 2 | 30.71 | 25.17 | 1.26 | 0.75–2.16 | 0.395 | 26.00 | 22.83 | 1.01 | 0.42–2.41 | 0.985 | 29.47 | 24.09 | 1.21 | 0.78–1.90 | 0.408 |
| UTR3 (DTCCCGAC) | |||||||||||||||
| Others | 86.07 | 87.41 | 1.00 | 78.00 | 84.25 | 1.00 | 83.95 | 85.95 | 1.00 | ||||||
| UTR 3 | 13.93 | 12.59 | 1.15 | 0.59–2.34 | 0.694 | 22.00 | 15.75 | 1.30 | 0.60–2.95 | 0.515 | 16.05 | 14.05 | 1.27 | 0.73–2.23 | 0.405 |
| UTR4 (DCGCCCAC) | |||||||||||||||
| Others | 91.79 | 86.73 | 1.00 | 88.00 | 93.31 | 1.00 | 90.79 | 89.78 | 1.00 | ||||||
| UTR 4 | 8.21 | 13.27 | 0.56 | 0.27–1.20 | 0.128 | 12.00 | 6.69 | 0.96 | 0.43–2.17 | 0.911 | 9.21 | 10.22 | 0.85 | 0.46–1.62 | 0.621 |
| UTR5 (ITCCTGAC) | |||||||||||||||
| Others | 87.50 | 91.16 | 1.00 | 87.00 | 91.34 | 1.00 | 87.37 | 91.24 | 1.00 | ||||||
| UTR 5 | 12.50 | 8.84 | 1.14 | 0.29–4.66 | 0.856 | 13.00 | 8.66 | 3.12 | 0.93–11.00 | 0.070 | 12.63 | 8.76 | 2.10 | 1.09–4.20 | 0.031c |
| UTR6 (DTGCCCAC) | |||||||||||||||
| Others | 94.29 | 92.52 | 1.00 | 87.37 | 91.24 | 1.00 | 93.68 | 91.79 | 1.00 | ||||||
| UTR 6 | 5.71 | 7.48 | 1.05 | 0.40–2.95 | 0.925 | 12.63 | 8.76 | 1.07 | 0.26–4.11 | 0.924 | 6.32 | 8.21 | 0.99 | 0.45–2.25 | 0.989 |
| UTR7 (ITCATGAC) | |||||||||||||||
| Others | 96.43 | 94.22 | 1.00 | 94.00 | 96.46 | 1.00 | 95.79 | 95.26 | 1.00 | ||||||
| UTR 7 | 3.57 | 5.78 | 0.44 | 0.15–1.33 | 0.131 | 6.00 | 3.54 | 5.98 | 0.91–34.34 | 0.054 | 4.21 | 4.74 | 0.80 | 0.31–2.17 | 0.654 |
UTR: (14-bp D/I; +3003C/T; +3010C/G; +3027A/G; +3035C/T; +3142C/G; +3187A/G; +3196C/G).
↵a, b, c After the Bonferroni correction, taking into account 7 independent tests (alphac = 0.0071), p values remained significant for “a” (p = 0.001) and “b” (p = 0.035), but did not remain significant in “c” (p = 0.215).
↵* Adjusted by sex, skin color, and age.
↵** Adjusted by sex, skin color, age, and place of origin.