Patient characteristics. A patient is considered to have high serum urate (sUA) if the average area under the curve for sUA levels is > 7 during the study period. Otherwise, the patient is considered to have low sUA. High versus low samples are used for survival analysis.
| Patients with No Kidney Disease Prior to Index Date | ||||
|---|---|---|---|---|
| Characteristics | All Patients, n = 2116 | High sUA, n = 1204 | Low sUA, n = 912 | p, High vs Low sUA |
| Demographic | ||||
| Age at 1st sUA test date, yrs; mean ± SD | 62.6 ± 11.63 | 61.1 ± 11.86 | 64.5 ± 11.04 | < 0.0001 |
| Race, n (%) | < 0.0001 | |||
| White | 1120 (53) | 565 (47) | 555 (61) | |
| Others | 996 (47) | 639 (53) | 357 (39) | |
| Region, n (%) | < 0.0001 | |||
| Arkansas | 341 (16) | 159 (13) | 182 (20) | |
| Louisiana | 368 (17) | 219 (18) | 149 (16) | |
| Mississippi | 1157 (55) | 695 (58) | 462 (51) | |
| Oklahoma | 223 (11) | 116 (10) | 107 (12) | |
| Texas | 27 (1) | 15 (1) | 12 (1) | |
| Body mass index, mean ± SD | 31.2 ± 6.79 | 31.5 ± 6.24 | 30.9 ± 7.45 | 0.0250 |
| Average no. of 6-month cycles during the study period, mean ± SD | 12.9 ± 4.37 | 12.6 ± 4.46 | 13.3 ± 4.22 | 0.0008 |
| Average no. of sUA values, mean ± SD | 3.9 ± 2.68 | 4.1 ± 2.99 | 3.6 ± 2.17 | 0.0001 |
| Index year, n (%) | 0.3930 | |||
| 2002 | 632 (30) | 340 (28) | 292 (32) | |
| 2003 | 576 (27) | 326 (27) | 250 (27) | |
| 2004 | 249 (12) | 143 (12) | 106 (12) | |
| 2005 | 209 (10) | 121 (10) | 88 (10) | |
| 2006 | 134 (6) | 78 (6) | 56 (6) | |
| 2007 | 116 (5) | 70 (6) | 46 (5) | |
| 2008 | 115 (5) | 76 (6) | 39 (4) | |
| 2009 | 85 (4) | 50 (4) | 35 (4) | |
| Comorbidities, n (%) | ||||
| Diabetes | 416 (20) | 205 (17) | 211 (23) | < 0.0001 |
| Hyperlipidemia | 1,412 (67) | 769 (64) | 643 (71) | 0.0010 |
| Hypertension | 1,964 (93) | 1,121 (93) | 843 (92) | 0.5530 |
| Smoking | 173 (8) | 116 (10) | 57 (6) | 0.0050 |