Table 3.

Association between joint symptoms and RA autoantibodies in the study groups. Data are percentages.

Hand JointsOther Joints
PainSwellingStiffnessPainSwellingStiffness
First-degree relatives
  RF+, n = 84504139543445
  RF−, n = 171523037562434
  ACPA+, n = 22504141645050
  ACPA−, n = 233523339552537
Controls
  RF+, n = 20422140*502030
  RF−, n = 338271016331525
  ACPA+, n = 7331429431429
  ACPA−, n = 329281117341525
All
  ACPA+ and RF+, n = 117355*66*82*64**64
  All others, n = 593372025421929
  • All comparisons are between autoantibody-positives (RF+, or ACPA+, or both) and all other individuals in that group.

  • * p < 0.05,

  • ** p < 0.01 after Bonferroni correction for 6 comparisons in each analysis (e.g., RF+ vs RF−). RA: rheumatoid arthritis; RF: rheumatoid factor; ACPA: anticitrullinated protein antibodies.