Association between joint symptoms and RA autoantibodies in the study groups. Data are percentages.
| Hand Joints | Other Joints | |||||
|---|---|---|---|---|---|---|
| Pain | Swelling | Stiffness | Pain | Swelling | Stiffness | |
| First-degree relatives | ||||||
| RF+, n = 84 | 50 | 41 | 39 | 54 | 34 | 45 |
| RF−, n = 171 | 52 | 30 | 37 | 56 | 24 | 34 |
| ACPA+, n = 22 | 50 | 41 | 41 | 64 | 50 | 50 |
| ACPA−, n = 233 | 52 | 33 | 39 | 55 | 25 | 37 |
| Controls | ||||||
| RF+, n = 20 | 42 | 21 | 40* | 50 | 20 | 30 |
| RF−, n = 338 | 27 | 10 | 16 | 33 | 15 | 25 |
| ACPA+, n = 7 | 33 | 14 | 29 | 43 | 14 | 29 |
| ACPA−, n = 329 | 28 | 11 | 17 | 34 | 15 | 25 |
| All | ||||||
| ACPA+ and RF+, n = 11 | 73 | 55* | 66* | 82* | 64** | 64 |
| All others, n = 593 | 37 | 20 | 25 | 42 | 19 | 29 |
All comparisons are between autoantibody-positives (RF+, or ACPA+, or both) and all other individuals in that group.
↵* p < 0.05,
↵** p < 0.01 after Bonferroni correction for 6 comparisons in each analysis (e.g., RF+ vs RF−). RA: rheumatoid arthritis; RF: rheumatoid factor; ACPA: anticitrullinated protein antibodies.