Two logistic regression models for association of multiple variables with having any joint symptom and also for all hand joint symptoms. Models were tested in the NAN population only (FDR and NAN controls).
| Variable | Any Joint Symptoms, n = 358/624 | All Hand Symptoms, n = 115/621* | ||
|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | |
| FDR | 2.2 (1.4–3.6) | 0.001 | 2.0 (1.1–3.6) | 0.02 |
| Female | 0.8 (0.5–1.2) | NS | 1.6 (0.9–2.8) | NS |
| Age | 1.1 (1.0–1.1) | < 0.001 | 1.1 (1.0–1.1) | < 0.001 |
| Urban | 1.7 (1.1–2.6) | 0.01 | 2.0 (1.2–3.4) | 0.01 |
| hsCRP | 1.0 (0.9–1.1) | NS | 1.0 (0.9–1.1) | NS |
| ACPA | 0.5 (0.2–1.3) | NS | 0.5 (0.1–2.4) | NS |
| RF | 1.0 (0.6–1.6) | NS | 1.3 (0.7–2.4) | NS |
| ACPA and RF | 11.4 (1.1–120) | 0.04 | 5.2 (0.7–39) | NS |
↵* Having pain, stiffness, and swelling of hand joints. FDR: first-degree relative; NAN: North American Native; ACPA: anticitrullinated protein antibodies; RF: rheumatoid factor; hsCRP: high-sensitivity C-reactive protein; NS: nonsignificant.