Comparison of single-nucleotide polymorphism (SNP)-associated low-density lipoprotein (LDL) cholesterol levels in patients with rheumatoid arthritis (RA) and diabetes mellitus.
| SNP | Allele | MAF | Major Allele Homozygotes | Heterozygotes | Minor Allele Homozygotes | p* | |||
|---|---|---|---|---|---|---|---|---|---|
| No. | LDL Cholesterol Levels, mg/dl | No. | LDL Cholesterol Levels, mg/dl | No. | LDL Cholesterol Levels, mg/dl | ||||
| RA | |||||||||
| rs688 | C/T | 0.179 | 211 | 128.2 ± 34.9 | 76 | 136.5 ± 40.1 | 14 | 159.6 ± 38.8 | ND |
| rs693 | C/T | 0.048 | 282 | 130.9 ± 36.5 | 11 | 143.7 ± 31.1 | 9 | 145.0 ± 55.7 | ND |
| rs4420638 | A/G | 0.157 | 222 | 130.8 ± 35.3 | 67 | 132.5 ± 39.8 | 13 | 150.9 ± 46.9 | ND |
| Diabetes mellitus | |||||||||
| rs688 | C/T | 0.130 | 205 | 133.0 ± 31.7 | 65 | 137.5 ± 34.8 | 3 | 155.1 ± 35.2 | 0.044 |
| rs693 | C/T | 0.042 | 250 | 134.7 ± 32.4 | 23 | 136.9 ± 30.7 | 0 | NA | 0.631 |
| rs4420638 | A/G | 0.095 | 223 | 134.4 ± 31.6 | 48 | 136.6 ± 34.5 | 2 | 149.6 ± 43.8 | 0.002 |
↵* Comparison of minor allele frequency between RA and diabetes mellitus after adjustment for age, sex, and use of statin. MAF: minor allele frequency; ND: not done; NA: not applicable.