Table 2.

All infections requiring hospitalization in 609 patients diagnosed with rheumatoid arthritis (RA) in 1955–1994 compared with 464 patients diagnosed with RA in 1995–2007.

Patients, nInfections, nIncidence/100 Person-years (all events/person-years)
Infection Type1955–19941995–20071955–19941995–20071955–19941995–2007RR* (95% CI)
Total290547401789.576.560.69 (0.58, 0.80)
Bacteremia/septicemia531060140.780.520.68 (0.36, 1.16)
Septic arthritis2032730.350.110.36 (0.08, 0.92)
Osteomyelitis1101300.170.000.11 (0.00, 0.59)
Pneumonia15528240543.101.990.65 (0.47, 0.85)
Lower respiratory tract571089101.150.370.33 (0.16, 0.59)
Urosepsis/pyelonephritis2743550.450.180.44 (0.15, 0.96)
Skin/soft-tissue10921183412.371.510.64 (0.45, 0.89)
Gastrointestinal infections261338340.491.252.55 (1.60, 4.04)
Intraabdominal2552650.340.180.59 (0.20, 1.33)
Other24829120.380.441.21 (0.59, 2.26)
Opportunistic infections††363110.040.419.35 (3.22, 41.4)
Clostridium difficile13160.010.2212.34 (2.84, 176.5)
  • * Rate ratio obtained by dividing infection incidence rates in 1995–2007 patients with RA by those in 1955–1994 patients.

  • Includes gastroenteritis, diverticulitis, infective colitis, Clostridium difficile, and vancomycin-resistant enterococci.

  • †† Includes Clostridium difficile and vancomycin-resistant enterococci.