Observed frequencies (%) for antinuclear antibodies (ANA) determined by indirect immunofluorescence in systemic sclerosis (SSc) patients with different patterns of nailfold microvascular damage (early, active, late) at the end of followup.
| ANA Pattern | Nailfold Videocapillaroscopy Pattern | |||||
|---|---|---|---|---|---|---|
| Early n (%) | Active n (%) | Late n (%) | Total n (%) | OR (95% CI) | p | |
| Negative | 7 (16.7) | 1 (2.4) | 0 (0) | 8 (19.1) | 0.1* (0.0–0.7) | 0.02 |
| Nucleolar | 0 (0) | 1 (2.4) | 1 (2.4) | 2 (4.8) | 4.0** (0.2–71.1) | 0.39 |
| Homogeneous | 1 (2.4) | 1 (2.4) | 1 (2.4) | 3 (7.2) | 1.9** (0.2–24.2) | 0.52 |
| Centromeric (ACA+) | 7 (16.7) | 7 (16.7) | 3 (7.1) | 17 (40.5) | 1.3* (0.4–4.6) 0.7** (0.1–3.2) | 0.76 0.72 |
| Speckled | 2 (4.8) | 0 (0) | 0 (0) | 2 (4.8) | ||
| Fine-speckled + nucleolar (Scl-70-positive) | 1 (2.4) | 2 (4.8) | 4 (9.5) | 7 (16.7) | 6.4* (0.7–58.4) 8.0** (1.4–47.0) | 0.11 0.03 |
| Speckled + nucleolar (Scl-70-negative) | 1 (2.4) | 2 (4.8) | 0 (0) | 3 (7.1) | ||
| Total | 19 (45.2) | 14 (33.3) | 9 (21.4) | 42 (100) | ||