Bone mineral density (BMD; g/cm2) results after anti-tumor necrosis factor-α therapy. Results are given as mean ± SD.
| Location | n | Baseline | 1 Year | 3 Years |
|---|---|---|---|---|
| Hand | 45 | 0.356 ± 0.045 | 0.357 ± 0.046 | 0.360 ± 0.056 |
| PIP periarticular | 45 | 0.287 ± 0.047 | 0.296 ± 0.048** | 0.305 ± 0.056** |
| MCP periarticular | 45 | 0.305 ± 0.042 | 0.299 ± 0.043* | 0.300 ± 0.043 |
| Total hip | 44 | 0.949 ± 0.132 | 0.952 ± 0.146 | 0.935 ± 0.139* |
| Lumbar spine | 45 | 0.949 ± 0.131 | 0.952 ± 0.146 | 0.936 ± 0.139 |
Repeated measures differences noted for periarticular PIP (p = 0.002), periarticular MCP (p = 0.016), and total hip (p = 0.014). Differences compared with baseline:
↵* p < 0.05,
↵** p < 0.01. Posthoc significance tests are adusted for multiple comparisons. No differences were noted between rheumatoid arthritis and psoriatic arthritis. PIP: proximal interphalangeal joints; MCP: metacarpophalangeal joints.