FVC | DLCO | CPI | ||||
---|---|---|---|---|---|---|
IPF | SSc | IPF | SSc | IPF | SSc | |
IL-6 | −0.43 (0.0007)† | −0.35 (0.002)† | −0.31 (0.02) | −0.23 (0.05) | 0.43 (0.0007)† | 0.29 (0.01) |
IL-8 | −0.39 (0.002)† | NS | −0.46 (0.0003)† | NS | 0.53 (< 0.00001)† | NS |
CCL2 | −0.35 (0.006)† | −0.26 (0.03) | −0.33 (0.01) | NS | 0.38 (0.003)† | 0.26 (0.02) |
IL-10 | −0.27 (0.04) | −0.29 (0.01) | NS | NS | 0.29 (0.03) | 0.27 (0.02) |
CXCL10 | −0.28 (0.03) | NS | NS | NS | 0.25 (0.05) | 0.24 (0.04) |
VEGF | −0.26 (0.05) | NS | −0.28 (0.03) | NS | 0.32 (0.01) | NS |
FGF2* | −0.28 (0.03) | −0.25 (0.03) | −0.26 (0.06) | −0.22 (0.05) | 0.29 (0.02) | 0.26 (0.02) |
CX3CL1* | −0.25 (0.05) | NS | NS | NS | NS | NS |
ESR | NS | NS | NS | NS | NS | NS |
↵* Analyzed as dichotomous variables. Spearman correlation for all variables, except for *point-biserial coefficient of correlation.
↵† Significant after Bonferroni correction. P values reported in parentheses when ≤ 0.05. IPF: idiopathic pulmonary fibrosis; SSc: systemic sclerosis; FVC: forced vital capacity; CPI: composite physiologic index; NS: not significant; IL: interleukin; VEGF: vascular endothelial growth factor; FGF2: fibroblast growth factor 2; ESR: erythrocyte sedimentation rate; chemokine abbreviations as on Appendix 3.