Table 4

Mean (SE) change from baseline in FACIT-fatigue scores at Weeks 12 and 24, and patients reporting improvements greater than or equal to minimal clinically important difference (≥ 4.0).

MeasurePlaceboFostamatinib 150 mg qdFostamatinib 100 mg bid
Mean (SE) change from baseline, FACIT-fatigue score
 Week 125.60 (0.87)5.30 (0.87)7.40 (0.90)
 Week 244.50 (0.94)5.70 (0.99)7.40 (1.00)*
Patients reporting improvements ≥ 4.0 in FACIT-fatigue score, %
 Week 1256.257.462.6
 Week 2448.660.759.8
  • Versus placebo.

  • * p < 0.05 (positive change reflects improvement). bid: twice daily; qd: once daily; FACIT-fatigue: Functional Assessment of Chronic Illness Therapy-Fatigue.