Main studies/case reports evaluating effectiveness of calcineurin inhibitors (cyclosporine and tacrolimus) in antisynthetase patients with ILD.
| Study | Pts Assessed | No. Anti-Jo-1 Pts | Immunosuppressant | Followup on Immunosuppressants, mo | Patients Improved | ILD Improvement | |
|---|---|---|---|---|---|---|---|
| PFT | HRCT | ||||||
| Present study | 17 | 17 | Cyclosporine | 96** | 17/17 | FVC, DLCO | Kazerooni score |
| Sauty29 | 4 | 4 | Cyclosporine (+ azathioprine) | 18** | 4/4 | TLC, FVC, DLCO | NA |
| Tellus27 | 1 | 1 | Cyclosporine | 60 | 1/1 | FVC, DLCO | NA |
| Wilkes14 | 12 | 12 | Tacrolimus | 36** | 12/12 | FVC, DLCO | NA |
| Guglielmi25 | 1 | 1 | Tacrolimus | 6 | 1/1 | NA | NA |
| Koreeda30 | 5* | 5 | Cyclosporine | 14** | 4/5 | Yes† | Yes† |
| Ingegnoli40 | 7†† | 7 | Cyclosporine | 12 | 0/7 | NA | Progression† |
↵* Other 9 patients not taking cyclosporine.
↵** Median.
↵† Data not further specified.
↵†† Eight other patients taking cyclophosphamide. ILD: interstitial lung disease; PFT: pulmonary function tests; HRCT: high-resolution computed tomography; FVC: forced vital capacity; TLC: total lung capacity; NA: not available.